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Relationship Between Helicobacter pylori Infection and Arteriosclerosis

Authors Furuto Y, Kawamura M, Yamashita J, Yoshikawa T, Namikawa A, Isshiki R, Takahashi H, Shibuya Y

Received 21 January 2021

Accepted for publication 1 April 2021

Published 23 April 2021 Volume 2021:14 Pages 1533—1540

DOI https://doi.org/10.2147/IJGM.S303071

Checked for plagiarism Yes

Review by Single anonymous peer review

Peer reviewer comments 3

Editor who approved publication: Dr Scott Fraser

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Yoshitaka Furuto, Mariko Kawamura, Jumpei Yamashita, Takahiro Yoshikawa, Akio Namikawa, Rei Isshiki, Hiroko Takahashi, Yuko Shibuya

Department of Hypertension and Nephrology, NTT Medical Centre, Tokyo, Japan

Correspondence: Yoshitaka Furuto
Department of Hypertension and Nephrology, NTT Medical Centre, 5-9-22, Higasi-Gotanda, Shinagawa-Ku, Tokyo, 141-8625, Japan
Tel +81 03-3448-6111
Fax +81 03-3448-6058
Email [email protected]

Abstract: It is reported that Helicobacter pylori (H. pylori) infection may be linked to non-digestive tract diseases, such as arteriosclerosis including dyslipidemia, diabetes, obesity, hypertension, and cardiovascular disease. Therefore, we reviewed recent studies available in PubMed dealing with the mechanisms of arteriosclerosis due to H. pylori infection and the effects of H. pylori eradication. Conventional studies suggested that H. pylori infection may increase the risk of arteriosclerosis. A large interventional study is required to clarify the causal relationships and the effects of bacterial eradication.

Keywords: Helicobacter pylori infection, arteriosclerosis, hypertension

Introduction

While it is widely known that Helicobacter pylori (H. pylori) may cause gastritis, gastric ulcer, gastric cancer, gastric lymphoma,1 idiopathic thrombocytopenic purpura,2 and iron-deficiency anemia,2 this infection may also be involved in non-digestive tract diseases such as chronic urticaria,3 Alzheimer’s disease,4 Parkinson's disease,5 atrial fibrillation,6 liver diseases,7 Behçet’s disease,8 hyperemesis gravidarum,9 infertility,10 glaucoma,11 alopecia areata,12 and arteriosclerosis disease13 including dyslipidemia,14,15 diabetes,16–18 obesity,19,20 hypertension,15,21–23 chronic kidney disease24 and cardiovascular disease.24–29 Several reports have indicated a relationship between H. pylori and acute coronary syndrome,25 which suggests that H. pylori infection is a risk factor for cardiovascular disease (CVD);24,26,27 moreover, patients with H. pylori infection show an approximately 3-times higher risk of coronary artery disease than do healthy individuals.28 Furthermore, in a study of H. pylori patients below 65 years of age, who were categorized into bacterial eradication or non-eradication groups, the eradication group showed a significantly lower incidence of coronary heart disease during a 1-year follow-up period.29 H. pylori infection was found to be an independent risk factor for carotid artery plaque and stroke.26

A relationship between H. pylori infection and lifestyle-based diseases has also been suggested. Associations of H. pylori infection with hypercholesterolemia,14 low levels of high-density lipoprotein-cholesterol (HDL-C), and high levels of low-density lipoprotein-cholesterol (LDL-C) have been reported.15 Several studies have found that H. pylori is associated with insulin resistance16 and diabetes mellitus.17,18 Furthermore, H. pylori infection has been reported to be positively correlated with body mass index (BMI).19 Among patients with chronic kidney disease, the risk of developing end-stage renal disease is 3.72-times higher for H. pylori-infected individuals than for patients without the infection.24 Hypertension has also been associated with H. pylori infection;15 H. pylori-positive hypertensive patients show significantly higher arterial blood pressure than that of hypertensive patients without the infection.21 Furthermore, the eradication of H. pylori has been reported to improve hypertension.22,23

Conversely, findings related to arteriosclerosis accompanied by H. pylori infection vary,5,30–39 and the relationship between both pathologies remains unclear. Moreover, while the precise nature of this relationship is still unclear, it is important to update this information because the eradication of H. pylori may be beneficial for treatment of arteriosclerosis. To fill current gaps in knowledge, we reviewed recent studies on the mechanisms of arteriosclerosis due to H. pylori infection and the effects of H. pylori eradication.

Methods

We performed a detailed review of the recent literature to study the relationship between H. pylori infection and arteriosclerosis. A literature screen was conducted by reviewing PubMed. We screened the following keywords: “Helicobacter pylori infection,” and/or “eradication” with “arteriosclerosis,” “hypertension,” “dyslipidemia,” “diabetes,” “obesity,” and “cardiovascular disease.” We examined the mechanism of arteriosclerosis by H. pylori infection and the role of eradication of H. pylori for arteriosclerosis. Moreover, we present a narrative review of the literature obtained from these screenings as brief summary. We have described the mechanism of disease onset in detail and the most recent information on the relationship between H. pylori infection and arteriosclerosis.

Helicobacter pylori Infection and Arteriosclerosis

H. pylori may influence the development of arteriosclerosis due to hypertension, as suggested in previous reports.15,21–23 Two possible explanations may account for the higher incidence of hypertension in H. pylori-positive patients. Firstly, high-salt intake, which is a known risk factor for hypertension, favors the colonization of H. pylori.40–42 Moreover, experiments in mice have shown that high-salt intake facilitates the formation of H. pylori colonies.40 Another study revealed that high-salt intake increases the surface mucous cell mucin with an affinity to H. pylori, decreases the H. pylori-resistant gland mucous cell mucin, and damages the gastric mucosal gel layer.41 As further proof, the 1991 EUROGAST study, which examined global H. pylori infection rates, revealed that the Akita region in Japan had the highest H. pylori infection rate (70%).42 Akita is located in the Tohoku region, where the diet is known for being particularly high in salt intake compared to the rest of Japan. The high H. pylori infection rate in Akita, a developed prefecture with elevated standards of hygiene, suggests a relationship between H. pylori infection rate and the high-salt diet.43 Therefore, the incidence of hypertension in a region with high-salt intake may be more closely associated with H. pylori presence than with H. pylori absence, although this most likely depends also on the levels of hygiene and sociocultural factors.44,45

Secondly, since epidemiological research46 indicates that H. pylori infection may be a new risk factor for CVD, the higher prevalence of hypertension in patients with H. pylori infection may be a result of the existence of factors specific to H. pylori that also play a role in arteriosclerosis. Possible mechanisms by which atherosclerosis could be caused by H. pylori have been reported (Box 1).23,27 H. pylori infection was reportedly associated with increased prevalence of metabolic syndrome, CVD, and high levels of fibrinogen, total cholesterol, uric acid, and blood glucose.26,47 Moreover, H. pylori causes persistent long-term infections48 that lead to chronic inflammation,27,49,50 platelet activation,28,51 dyslipidemia,14,15,52 glucose intolerance,16–18,53 hyperhomocysteinemia,27,54 increased resorption of sodium due to elevated ammonia levels in the digestive tract,23 direct invasion of the vascular walls,55,56 and reaction in atheromas.28 Additionally, chronic inflammation due to H. pylori infection activates a variety of chemical mediators that have been linked to endothelial dysfunction.49 Specifically, H. pylori increases the levels of tumor necrosis factor (TNF)-α, interleukin (IL)-1, IL-6, IL-8, gamma interferon, fibrinogen, thrombin, intercellular adhesion molecule, and vascular cell adhesion molecule; these inflammatory cytokines directly or indirectly damage the vascular walls, thereby causing arteriosclerosis.57–59

Box 1 Possible Mechanisms by Which Atherosclerosis May Be Caused by Helicobacter pylori

H. pylori also causes an immune response through the activation of cyclooxygenase enzyme-2 (COX-2), which increases the production of prostaglandin and nitric oxide (NO).27 Lipopolysaccharide (LPS) on the H. pylori cell wall activates Toll-like receptor-4, which activates secondary mediators, such as mitogen-activated protein kinase, extracellular-signal-regulated kinase, c-Jun N-terminal kinase, and p38 kinase, and further stimulates NO synthase and COX-2 gene expression.60,61 This immune response to LPS could also increase the risk of atherosclerosis.62

Another mechanism related to chronic inflammation is the antigen cross-reactivity of H. pylori, which has been shown to activate an autoimmune response that causes vascular endothelial damage.63 Antigenic cross-reactivity between human heat shock protein and H. pylori has been reported to cause coronary artery calcification and atherosclerosis;64,65 as well as the activation of helper T-cells.66

CagA (cytotoxin-associated gene A) is a very important H. pylori virulence factor associated with a greater inflammatory response.67,68 After CagA undergoes tyrosine phosphorylation in gastric epithelial cells, it can induce a variety of cellular responses, including cell proliferation, cell movement, and suppression of cell death.69 CagA-positive H. pylori patients showed a higher risk of CVD and stroke.27,70,71 CagA, at a molecular level, mimics human tropomyosin and cardiac adenosine triphosphatase that can cause myocardial damage;72,73 it also promotes secretion of cytokines that induce severe inflammation and atherosclerotic destabilization.50 Moreover, CagA was reported to promote arteriosclerosis by increasing the levels of COX-1 and COX-2 in the vascular endothelium, thus promoting prostacyclin production, platelet activation,50 and increased levels of oxidized LDL-C, high-sensitivity C-reactive protein (CRP), and Apolipoprotein B.72

H. pylori infection has been reported to induce thromboxane, which activates platelets28 and promotes their binding to the Von Willebrand factor, causing platelet aggregation and destabilization of atherosclerotic plaques.51 Furthermore, TNF-α, interferon-α, IL-6, and IL-1, which are activated due to H. pylori infection, in turn, activate lipoprotein lipase, which can affect lipid metabolism and result in dyslipidemia.52

In relation to glucose intolerance, H. pylori-positive patients have elevated levels of the oxidative stress marker paraoxonase, suggesting a relationship between this infection and oxidative stress.53 Additionally, atrophic gastritis due to H. pylori infection leads to vitamin B12 and folic acid deficiency, which results in hyperhomocysteinemia, and damages the vascular endothelial cells.27 Increased ammonia in the intestinal tract and the accompanying intestinal spasms are induced through H. pylori infection, which can damage absorption within the digestive tract and result in increased resorption of sodium through the kidney, causing hypertension.23

Invasion of H. pylori into atheromas has been observed using PCR.55 Direct H. pylori colonization in the arterial walls has also been suggested.56 In addition, H. pylori reacts with monocytes and activates the proliferation of fibroblasts in atheromas.28 Therefore, H. pylori has been linked to arteriosclerosis through a variety of mechanisms, thus potentially causing hypertension. H. pylori infection may independently be involved in atherosclerosis and hypertension through mechanisms that differ from the classical well-known causes of arteriosclerosis.

H. pylori eradication results in a variety of reported outcomes in patients. This holds true for atherosclerosis-related disease; according to recent research (Table 1), outcomes include increased HDL-C,74–78 apolipoprotein AI, apolipoprotein AII,77 and BMI levels,74 as well as higher diastolic blood pressure,74 decreased levels of CRP,74–76 fibrinogen,74,79 total oxidant status,80,81 LDL-C,75 total cholesterol,75,82 triglycerides,75 insulin resistance,75 BMI,82 blood pressure,22,23 coronary artery lumen,83 and coronary heart disease29 and improved endothelial dysfunction84 (Table 2). Although there might be favorable effects of treating H. pylori on arteriosclerosis, in some studies the effects of H. pylori eradication on sugar,85 lipid and fibrinolytic parameters,85,86 inflammatory parameters and platelet activation markers87 were not confirmed. The contradictory results for BMI and blood pressure might be related to the study design;74 the effects of H. pylori eradication are controversial.

Table 1 Recent Research Regarding the Role of Eradication of Helicobacter pylori in the Evolution of Atherosclerosis-Related Disease

Table 2 Change in Atherosclerosis Markers After Eradication of Helicobacter pylori

The incidence of H. pylori infection is influenced by social, economic, cultural, regional, and sanitary factors. Large, long-term, prospective, randomized controlled, interventional studies are required to elucidate the role of eradication for H. pylori infection.

Conclusion

H. pylori infection may increase the risk of arteriosclerosis through mechanisms other than those classically associated with the disease. A large interventional study is required to clarify the causal relationships and effects of bacterial eradication.

Abbreviations

CVD, cardiovascular disease; HDL-C, high-density lipoprotein-cholesterol; LDL-C, low-density lipoprotein-cholesterol; BMI, body mass index; TNF, tumor necrosis factor; IL, interleukin; COX, cyclooxygenase enzyme; LPS, lipopolysaccharide; NO, nitric oxide; CagA, cytotoxin-associated gene A; CRP, C-reactive protein.

Acknowledgments

We would like to thank Editage for English language editing.

Author Contributions

YF: Conceptualization; YF, MK, JY, TY, AN, RI, HT, and YS: Data curation; YF: Formal analysis; YF: Investigation; YF: Methodology; YF: Project administration; YF: Supervision; YF: Validation; YF: Roles/Writing; YF: original draft; YF: Writing; YF: review & editing. All authors read and approved the final manuscript.

All authors made substantial contributions to conception and design, acquisition of data, or analysis and interpretation of data; took part in drafting the article or revising it critically for important intellectual content; agreed to submit to the current journal; gave final approval of the version to be published; and agree to be accountable for all aspects of the work.

Funding

This work was not supported by any funding.

Disclosure

The authors report no conflicts of interest in this work.

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