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Relationship between depression and medication adherence in cardiovascular disease: the perfect challenge for the integrated care team

Authors Goldstein CM, Gathright EC, Garcia S

Received 10 November 2016

Accepted for publication 3 February 2017

Published 15 March 2017 Volume 2017:11 Pages 547—559

DOI https://doi.org/10.2147/PPA.S127277

Checked for plagiarism Yes

Review by Single-blind

Peer reviewers approved by Dr Akshita Wason

Peer reviewer comments 2

Editor who approved publication: Dr Johnny Chen

Carly M Goldstein,1,2 Emily C Gathright,1,3 Sarah Garcia4

1Department of Psychiatry and Human Behavior, Warren Alpert Medical School of Brown University, 2Weight Control and Diabetes Research Center, The Miriam Hospital, Providence, RI, 3Department of Psychological Sciences, Kent State University, Kent, OH, 4Neuropsychology Section, Department of Psychiatry, University of Michigan, Ann Arbor, MI, USA

Abstract: Many individuals with cardiovascular disease (CVD) experience depression that is associated with poor health outcomes, which may be because of medication nonadherence. Several factors influence medication adherence and likely influence the relationship between depression and medication adherence in CVD patients. This comprehensive study reviews the existing literature on depression and medication adherence in CVD patients, addresses the methods of and problems with measuring medication adherence, and explains why the integrated care team is uniquely situated to improve the outcomes in depressed CVD patients. This paper also explores how the team can collaboratively target depressive symptoms and medication-taking behavior in routine clinical care. Finally, it suggests the limitations to the integrated care approach, identifies targets for future research, and discusses the implications for CVD patients and their families.

Keywords: cardiovascular disease, medication adherence, self-management, electronic monitoring, integrated care, collaborative care, compliance

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