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Relationship between computed tomography morphology and prognosis of patients with stage I non-small cell lung cancer

Authors Ma J, Yang Y, Wang Y, Zhang X, Gu X, Wang Z

Received 14 June 2016

Accepted for publication 14 December 2016

Published 21 April 2017 Volume 2017:10 Pages 2249—2256

DOI https://doi.org/10.2147/OTT.S114960

Checked for plagiarism Yes

Review by Single-blind

Peer reviewers approved by Dr Akshita Wason

Peer reviewer comments 2

Editor who approved publication: Dr XuYu Yang

Jun Ma,1,2 Yun-Long Yang,3 Ye Wang,2 Xue-Wei Zhang,2 Xue-Song Gu,2 Zhen-Chang Wang1

1Department of Radiology, Beijing Friendship Hospital, Capital Medical University, Beijing, 2Department of Radiology, 3Department of Thoracic Surgery, The Affiliated Hospital of Beihua University, Jilin, People’s Republic of China

Abstract: This study aimed to explore the relationship between computed tomography ­morphology and prognosis of patients with stage I non-small cell lung cancer (NSCLC). From May 2009 to May 2011, a total of 124 patients diagnosed with stage I NSCLC were included. All patients had complete chest computed tomography scans. Five-year follow-up was conducted. Univariate and multivariate Cox regression analyses were performed to estimate the prognostic factors for patients with stage I NSCLC. The 5-year survival rate was 67.74% (84/124). The 5-year survival rates of patients with stage T1a, T1b, and T2a were 89.19%, 75.00%, and 41.86%, respectively. The 5-year survival rates of patients with homogeneity, inhomogeneity, vacuole, and cavity were 68.42%, 72.09%, 59.46%, and 83.33%, respectively. The 5-year survival rates of patients with different margin features were 83.33% (slick margin), 79.73% (lobulation sign), and 39.47% (short burr). The 5-year survival rates of patients with normal, halo, vessel convergence, bronchial transection, and vascular bundle thickening were 84.38%, 72.73%, 71.79%, 52.00%, and 47.06%, respectively. The 5-year survival rates of patients with normal and pleura thickening/indentation were 81.93% and 39.02%. Univariate analysis demonstrated that tumor node metastasis staging, tumor margin, tumor periphery, and pleural invasion were related to the prognosis of stage I NSCLC patients. Cox regression analysis confirmed that T2a stage, pleura thickening/indentation were independent risk factors for poor prognosis of stage I NSCLC. In conclusion, our findings indicate that T2a stage, pleura thickening/indentation might be prognostic factors in stage I NSCLC.

Keywords: follow-up, survival rate, tumor node metastasis staging, tumor margin, tumor periphery, pleural thickening, pleural indentation

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