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Relation of high neuroticism with increased methylation of the BDNF gene

Authors Shirata T, Suzuki A, Matsumoto Y, Takahashi N, Noto K, Goto K, Otani K

Received 30 March 2018

Accepted for publication 15 May 2018

Published 9 July 2018 Volume 2018:14 Pages 1787—1793

DOI https://doi.org/10.2147/NDT.S169787

Checked for plagiarism Yes

Review by Single-blind

Peer reviewers approved by Dr Colin Mak

Peer reviewer comments 2

Editor who approved publication: Dr Taro Kishi


Toshinori Shirata,1 Akihito Suzuki,1 Yoshihiko Matsumoto,1 Nana Takahashi,1 Keisuke Noto,1 Kaoru Goto,2 Koichi Otani1

1Department of Psychiatry, Yamagata University School of Medicine, Yamagata, Japan; 2Department of Anatomy and Cell Biology, Yamagata University School of Medicine, Yamagata, Japan

Background: Brain-derived neurotrophic factor (BDNF) is a neurotrophin that has an important function in neuroplasticity and neuronal development. It is suggested that increased methylation of the BDNF gene resulting in decreased BDNF activity is associated with depression. Meanwhile, neuroticism is a well-known risk factor for developing depression. In the present study, the relationship between methylation of the BDNF gene and personality traits including neuroticism was examined.
Subjects and methods: The subjects were 98 healthy Japanese. Methylation levels of the BDNF gene were determined by the bisulfite-pyrosequencing method. Personality traits including neuroticism were assessed by the NEO Personality Inventory-Revised.
Results:
There was a positive correlation between neuroticism scores and methylation levels of the BDNF gene. The subjects with higher neuroticism scores had higher levels of BDNF gene methylation compared with those with lower neuroticism scores. Meanwhile, other personality traits were not associated with BDNF gene methylation.
Conclusion: The present study suggests that high neuroticism is related to increased methylation of the BDNF gene.

Keywords:
BDNF, depression, epigenetics, methylation, neuroticism

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