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Refractory healing after surgical therapy of osteonecrosis of the jaw: associated risk factors in aged patients

Authors Kim JY, Song HC, Jee HG

Received 4 January 2019

Accepted for publication 8 March 2019

Published 6 May 2019 Volume 2019:14 Pages 797—804

DOI https://doi.org/10.2147/CIA.S200455

Checked for plagiarism Yes

Review by Single-blind

Peer reviewers approved by Ms Justinn Cochran

Peer reviewer comments 3

Editor who approved publication: Dr Richard Walker


Ji-Youn Kim,1 Hyun Chul Song,1 Hyeon-Gun Jee2

1Division of Oral & Maxillofacial Surgery, Department of Dentistry, St. Vincent’s Hospital, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea; 2Healthcare Innovation Park, Seoul National University Bundang Hospital, Seongnam, Republic of Korea

Purpose: Osteonecrosis of the jaw (ONJ), both medication-related and non medication-related, mainly occurs in aged patients. It needs surgical intervention. Refractory healing after an operation of ONJ can significantly lower the quality of life of elderly patients. The purpose of this study was to determine risk factors associated with refractory healing in aged patients.
Patients and methods: We performed a retrospective study of ONJ in aged patients who underwent surgical treatments in a single institute during a 12-year period. Multiple logistic regression analysis was used to determine independent risk factors associated with refractory healing.
Results: A total of 122 patients were included. Of them, 25 patients were identified as the refractory group and 97 patients as the control group. Diabetes mellitus (DM) (AOR=5.03, 95% CI: 1.74–14.52) and glucocorticoid administration (AOR=7.97, 95% CI: 2.52–25.23) were found to be significant risk factors for refractory healing of ONJ.
Conclusion: DM and medication of glucocorticoid might be risk factors for refractory healing of ONJ.

Keywords: osteomyelitis, osteonecrosis, medication-related osteonecrosis of the jaw, surgical therapy, refractory healing, diabetes mellitus, glucocorticoid


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