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Recurrent respiratory papillomatosis: current and future perspectives

Authors Carifi M, Napolitano D, Morandi M, Dall’Olio D

Received 29 January 2015

Accepted for publication 5 March 2015

Published 5 May 2015 Volume 2015:11 Pages 731—738

DOI https://doi.org/10.2147/TCRM.S81825

Checked for plagiarism Yes

Review by Single-blind

Peer reviewer comments 2

Editor who approved publication: Professor Garry Walsh

Marco Carifi,1 Domenico Napolitano,1 Morando Morandi,1 Danilo Dall’Olio2

1Department of Otolaryngology, Azienda Ospedaliera di Rilievo Nazionale A Cardarelli, Naples, 2Department of Otolaryngology, Ospedale Maggiore CA Pizzardi, Bologna, Italy

Abstract: Although recurrent respiratory papillomatosis is a benign disease of the upper aerodigestive tract caused by infection with human papillomavirus, the disease process is unpredictable, ranging from mild disease and spontaneous remission to an aggressive disease with pulmonary spread and requirement for frequent surgical debulking procedures. It can present a protracted clinical course and cause potentially life-threatening compromise of the airways. Over recent decades, a number of alternative medical therapies to standard surgical treatment have been investigated, with modest outcomes overall. Currently, some additional therapies are being explored, together with novel surgical instrumentation that can help to avoid inevitable long-term stenotic complications, ultimately affecting quality of life. Hopefully, clinicians might soon be able to significantly improve the quality of treatment and outcomes for patients affected with recurrent respiratory papillomatosis, with human papillomavirus vaccination having a potentially important role.

Keywords: recurrent respiratory papillomatosis, laryngeal papillomatosis, adjuvant, cidofovir, bevacizumab, photodynamic therapy, microdebrider, angiolytic laser, celecoxib, HspE7

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