Recent advances of chitosan nanoparticles as drug carriers
Jun Jie Wang1, Zhao Wu Zeng1,2, Ren Zhong Xiao1, Tian Xie1, Guang Lin Zhou1, Xiao Ri Zhan1, Shu Ling Wang1
1Research Center for Biomedicine and Health, Hangzhou Normal University, Hangzhou, Zhejiang, People's Republic of China; 2College of Pharmaceutical Sciences, Zhejiang Chinese Medical University, Hangzhou, Zhejiang, People's Republic of China
Abstract: Chitosan nanoparticles are good drug carriers because of their good biocompatibility and biodegradability, and can be readily modified. As a new drug delivery system, they have attracted increasing attention for their wide applications in, for example, loading protein drugs, gene drugs, and anticancer chemical drugs, and via various routes of administration including oral, nasal, intravenous, and ocular. This paper reviews published research on chitosan nanoparticles, including its preparation methods, characteristics, modification, in vivo metabolic processes, and applications.
Keywords: chitosan nanoparticle, drug delivery system, preparation, modification, application