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Recent Advances in Macrophage-Mediated Drug Delivery Systems

Authors Liang T, Zhang R, Liu X, Ding Q, Wu S, Li C, Lin Y, Ye Y, Zhong Z, Zhou M

Received 19 December 2020

Accepted for publication 14 February 2021

Published 7 April 2021 Volume 2021:16 Pages 2703—2714

DOI https://doi.org/10.2147/IJN.S298159

Checked for plagiarism Yes

Review by Single anonymous peer review

Peer reviewer comments 3

Editor who approved publication: Dr Mian Wang


Tiantian Liang,1,* Rongtao Zhang,1,* Xianbin Liu,1,* Qian Ding,1 Siqiong Wu,1 Chunhong Li,2 Yan Lin,2 Yun Ye,1 Zhirong Zhong,2 Meiling Zhou1

1Department of Pharmacy, The Affiliated Hospital of Southwest Medical University, Luzhou, Sichuan, 646000, People’s Republic of China; 2Department of Pharmaceutical Sciences, School of Pharmacy, Southwest Medical University, Luzhou, Sichuan, 646000, People’s Republic of China

*These authors contributed equally to this work

Correspondence: Meiling Zhou
Department of Pharmacy, The Affiliated Hospital of Southwest Medical University, No. 25, Taiping Street, Luzhou, Sichuan, 646000, People’s Republic of China
Email [email protected]
Zhirong Zhong
Department of Pharmaceutical, Sciences School of Pharmacy, Southwest Medical University, No. 319 Zhongshan Road Jiangyang District, Luzhou, Sichuan, 646000, People’s Republic of China
Email [email protected]

Abstract: Macrophages have been extensively used in the development of drug delivery systems, as they can prolong the circulation and release of drugs, extend their half-life, increase their stability and targeting ability, and reduce immunogenicity. Moreover, they have good biocompatibility and degradability and offer abundant surface receptors for targeted delivery of a wide variety of drugs. Macrophage-mediated drug delivery systems can be prepared by loading drugs or drug-loaded nanoparticles into macrophages, macrophage membranes or macrophage-derived vesicles. Although such systems can be used to treat inflammation, cancer, HIV infection and other diseases, they require further research and optimization since they have been assembled from diverse sources and therefore can have quite different physical and chemical properties. Moreover, potential cell-drug interactions can limit their application, and the biological activity of membrane proteins might be lost during membrane extraction and storage. In this review, we summarize the recent advances in this field and discuss the preparation of macrophage-mediated drug delivery systems, their advantages over other delivery systems, their potential applications and future lines of research.

Keywords: macrophage, macrophage membranes, drug delivery systems, inflammation, tumor, biomimetic

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