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Recent Advances in Designing 5-Fluorouracil Delivery Systems: A Stepping Stone in the Safe Treatment of Colorectal Cancer

Authors Entezar-Almahdi E, Mohammadi-Samani S, Tayebi L, Farjadian F

Received 10 April 2020

Accepted for publication 29 June 2020

Published 30 July 2020 Volume 2020:15 Pages 5445—5458

DOI https://doi.org/10.2147/IJN.S257700

Checked for plagiarism Yes

Review by Single-blind

Peer reviewer comments 3

Editor who approved publication: Prof. Dr. Anderson Oliveira Lobo


Elaheh Entezar-Almahdi,1 Soliman Mohammadi-Samani,1,2 Lobat Tayebi,3 Fatemeh Farjadian2

1Department of Pharmaceutics, Faculty of Pharmacy, Shiraz University of Medical Sciences, Shiraz, Iran; 2Pharmaceutical Sciences Research Center, Shiraz University of Medical Sciences, Shiraz, Iran; 3Marquette University, School of Dentistry, Milwaukee, WI, USA

Correspondence: Fatemeh Farjadian
Pharmaceutical Sciences Research Center, Shiraz University of Medical Sciences, Shiraz 71348-14336, Iran
Tel +987132424127(302)
Email farjadian_f@sums.ac.ir

Abstract: 5-Fluorouracil (5-FU) has become one of the most widely employed antimetabolite chemotherapeutic agents in recent decades. It is considered a first line antineoplastic agent for the treatment of colorectal cancer. Unfortunately, chemotherapy with 5-FU has several limitations, including its short half-life, high cytotoxicity and low bioavailability. In order to overcome the drawbacks of 5-FU and enhance its therapeutic efficiency, many scientific groups have focused on designing a new delivery system to successfully deliver 5-FU to tumor sites. We provide a comprehensive review on different strategies to design effective delivery systems, including nanoformulations, drug-conjugate formulations and other strategies for the delivery of 5-FU to colorectal cancer. Furthermore, co-delivery of 5-FU with other therapeutics is discussed. This review critically highlights the recent innovations in and literature on various types of carrier system for 5-FU.

Keywords: 5-fluorouracil, drug delivery, colorectal cancer, nanomedicine, nanoparticles, co-delivery

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