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Real-world impact of education: treating patients with ipilimumab in a community practice setting

Authors Ledezma B, Heng A

Received 6 August 2013

Accepted for publication 23 September 2013

Published 21 December 2013 Volume 2014:6 Pages 5—14

DOI https://doi.org/10.2147/CMAR.S52543

Checked for plagiarism Yes

Review by Single-blind

Peer reviewer comments 5


Blanca Ledezma,1 Annie Heng2

1Department of Hematology and Oncology, University of California, Los Angeles, Santa Monica, CA, USA; 2Angeles Clinic and Research Institute, Los Angeles, CA, USA


Abstract: After decades without promising new treatments for advanced and metastatic melanoma, ipilimumab was the first systemic therapy approved for use in this patient population. A fully human monoclonal antibody that blocks cytotoxic T-lymphocyte antigen 4 (CTLA-4) to augment antitumor T-cell responses, ipilimumab significantly extended overall survival in clinical trials. Because ipilimumab is associated with a set of immune-related adverse events that likely reflect the agent's mechanism of action, a management guide has been established. Nurses play a significant role in initially identifying these adverse reactions and assisting in patient education, treatment, and follow-up. Herein, we discuss commonly asked questions related to ipilimumab therapy and treatment of adverse events, and how nurses can be prepared to answer these questions as they arise from patients and caregivers.

Keywords: melanoma, immunotherapy, patient education


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