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Randomized controlled trial on the safety of intracameral cephalosporins in cataract surgery

Authors Philip TH Lam, Alvin L Young, Lulu L Cheng, et al

Published 8 December 2010 Volume 2010:4 Pages 1499—1504

DOI https://doi.org/10.2147/OPTH.S15602

Review by Single-blind

Peer reviewer comments 2

Philip TH Lam, Alvin L Young, Lulu L Cheng, Patrick MK Tam, Vincent YW Lee
Department of Ophthalmology and Visual Sciences, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong SAR, China

Objective: To compare the safety profiles of intracameral cephalosporins in cataract surgery.
Patients and methods: In this controlled trial, 129 patients were randomized to one of four groups to receive 1 mg of one of three cephalosporins – cefazolin, cefuroxime, or ceftazidime, or normal saline – given intracamerally during cataract surgery. Central endothelial cell density (ECD) and retinal center point thickness (CPT) were determined by specular microscopy and ocular coherence tomography, respectively, before and at 3 months after surgery.
Results: There were no statistical significant differences in the changes of ECD and CPT between eyes receiving intracameral cephalosporin and control.
Conclusion: The use of intracameral cefazolin, cefuroxime, or ceftazidime (1 mg in 0.1-mL solution) at the time of cataract surgery had no significant effect on ECD and CPT postoperatively.

Keywords: intracameral cephalosporin, endophthalmitis, phacoemulsification

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