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Raltegravir in combination with other antiretroviral agents for the treatment of HIV infection

Authors Lisa M Chirch, Roy T Steigbigel

Published 26 April 2010 Volume 2010:3 Pages 15—23

DOI https://doi.org/10.2147/IDR.S9689

Review by Single-blind

Peer reviewer comments 2

Lisa M Chirch, Roy T Steigbigel

Division of Infectious Diseases, Department of Medicine, Stony Brook University Medical Center, Stony Brook, New York, USA

Abstract: Raltegravir, an inhibitor of the HIV-1 integrase enzyme, is the first available agent in a new class of antiretroviral drugs. Raltegravir has been studied extensively in clinical trials, and has been well tolerated and highly effective in both treatment-naïve and -experienced patients. Resistance to raltegravir is unusual given its recent availability, but resistance with identified viral mutation pathways in the integrase gene in patients receiving the drug does occur.
Keywords: raltegravir, integrase, human immunodeficiency virus, drug resistance

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