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Radiotherapy for one rectal cancer patient with cirrhosis and moderate to severe thrombocytopenia: a case report

Authors Shi X, Xia H, Zhang W, Li G, Li A

Received 18 May 2018

Accepted for publication 2 August 2018

Published 27 August 2018 Volume 2018:11 Pages 5203—5207


Checked for plagiarism Yes

Review by Single anonymous peer review

Peer reviewer comments 3

Editor who approved publication: Dr Leo Jen-Liang Su

Xinqi Shi, Huifang Xia, Weiwei Zhang, Guang Li, Ailin Li

Department of Radiation Oncology, The First Hospital of China Medical University, Shenyang, Liaoning, China

Abstract: When patients with cirrhosis and severe thrombocytopenia suffer malignant tumors, there is usually no effective and feasible treatment method due to the high risk of hemorrhage. Herein, we report a case in which radiotherapy was given to a patient with a strong desire for the treatment. The patient was a 66-year-old man with a 13-year history of cirrhosis and a 10-year history of thrombocytopenia, and was diagnosed with locally advanced rectal cancer (LARC; T4aN1M0, stage IIIB). The platelet count before radiotherapy was 32 × 109/L, and the blood coagulation was normal. The severity of thrombocytopenia increased after 2 Gy × 7 fractions pelvic radiation, with platelet counts dropping to 16 × 109/L. Platelet counts failed to return to pre-therapy levels after supporting therapy including recombinant human interleukin 11 subcutaneous injection and platelet transfusion. Although radiotherapy was discontinued eventually, the data presented here represent a valuable resource that can help inform treatment decisions for tumor patients with cirrhosis and thrombocytopenia.

Keywords: rectal cancer, liver cirrhosis, thrombocytopenia, radiotherapy

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