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Radiologic Complete Response In Lung Adenocarcinoma With Symptomatic Brain Metastasis After Systematic Therapy: A Case Study
Authors Chen J, Wang J, Zheng Q, Weng M, Wu X
Received 10 August 2019
Accepted for publication 23 October 2019
Published 11 November 2019 Volume 2019:12 Pages 9551—9557
DOI https://doi.org/10.2147/OTT.S226735
Checked for plagiarism Yes
Review by Single anonymous peer review
Peer reviewer comments 2
Editor who approved publication: Dr Sanjeev Srivastava
Jianxin Chen,1 Junhui Wang,2 Qinhong Zheng,1 Meiling Weng,1 Xilin Wu1
1Department of Medical Oncology, Quzhou People’s Hospital, Quzhou, Zhejiang 324000, People’s Republic of China; 2Department of Radiation Oncology, Quzhou People’s Hospital, Quzhou, Zhejiang 324000, People’s Republic of China
Correspondence: Xilin Wu
Department of Medical Oncology, Quzhou People’s Hospital, Quzhou, Zhejiang 324000, People’s Republic of China
Email wuxilin1544@163.com
Abstract: Patients diagnosed as lung adenocarcinoma with brain metastasis usually result in poor prognosis with limited survival time. Palliative systematic therapy has emerged as the primary choice for non-small cell lung cancer patients with brain metastasis harboring wild-type drive genes. However, the objective response rate and long-term survival for patients treated with this therapy remained unsatisfied. Herein, we present a case with lung adenocarcinoma accompanied with symptomatic brain metastasis who achieved radiologic complete response after receiving combined therapy including stereotactic body radiation therapy, anti-angiogenesis, and chemotherapy. He has achieved a duration of disease-free survival of thirty-six months, and is still in extension.
Keywords: complete response, lung adenocarcinoma, brain metastasis, systematic therapy
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