Back to Journals » OncoTargets and Therapy » Volume 12

Radiologic Complete Response In Lung Adenocarcinoma With Symptomatic Brain Metastasis After Systematic Therapy: A Case Study

Authors Chen J, Wang J, Zheng Q, Weng M, Wu X

Received 10 August 2019

Accepted for publication 23 October 2019

Published 11 November 2019 Volume 2019:12 Pages 9551—9557

DOI https://doi.org/10.2147/OTT.S226735

Checked for plagiarism Yes

Review by Single anonymous peer review

Peer reviewer comments 2

Editor who approved publication: Dr Sanjeev Srivastava


Jianxin Chen,1 Junhui Wang,2 Qinhong Zheng,1 Meiling Weng,1 Xilin Wu1

1Department of Medical Oncology, Quzhou People’s Hospital, Quzhou, Zhejiang 324000, People’s Republic of China; 2Department of Radiation Oncology, Quzhou People’s Hospital, Quzhou, Zhejiang 324000, People’s Republic of China

Correspondence: Xilin Wu
Department of Medical Oncology, Quzhou People’s Hospital, Quzhou, Zhejiang 324000, People’s Republic of China
Email wuxilin1544@163.com

Abstract: Patients diagnosed as lung adenocarcinoma with brain metastasis usually result in poor prognosis with limited survival time. Palliative systematic therapy has emerged as the primary choice for non-small cell lung cancer patients with brain metastasis harboring wild-type drive genes. However, the objective response rate and long-term survival for patients treated with this therapy remained unsatisfied. Herein, we present a case with lung adenocarcinoma accompanied with symptomatic brain metastasis who achieved radiologic complete response after receiving combined therapy including stereotactic body radiation therapy, anti-angiogenesis, and chemotherapy. He has achieved a duration of disease-free survival of thirty-six months, and is still in extension.

Keywords: complete response, lung adenocarcinoma, brain metastasis, systematic therapy

Creative Commons License This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution - Non Commercial (unported, v3.0) License. By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms.

Download Article [PDF]  View Full Text [HTML][Machine readable]