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Quantitative assessment of caveolin-1 G14713A polymorphism and cancer susceptibility in the Asian population

Authors Tang J, Wang G, Li Q, Song R

Received 20 July 2015

Accepted for publication 14 October 2015

Published 10 March 2016 Volume 2016:9 Pages 1381—1387

DOI https://doi.org/10.2147/OTT.S92736

Checked for plagiarism Yes

Review by Single-blind

Peer reviewers approved by Dr Ram Prasad

Peer reviewer comments 4

Editor who approved publication: Professor Daniele Santini


Jianjun Tang,1,* Gang Wang,2,* Qiang Li,1 Rongfeng Song1

1Department of Gastroenterology, Cancer Hospital of Jiangxi Province, Nanchang, Jiangxi, 2State Key Laboratory of Oncology in South China, Sun Yat-Sen University Cancer Center, Guangzhou, People’s Republic of China

*These authors contributed equally to this work

Purpose: The relationship between caveolin-1 (CAV1) G14713A polymorphism and cancer susceptibility remains inconclusive. The current meta-analysis was performed on the basis of a systematic search in electronic databases for a more precise estimation of the associations.
Methods: Odds ratio (OR) with 95% confidence interval (CI) was used to estimate the pooled effect.
Results: A total of 12 studies including 4,994 cases and 5,606 controls were involved in this meta-analysis. In the overall analysis, CAV1 G14713A polymorphism was significantly associated with an increased risk of cancer (A vs G: OR =1.77, 95% CI: 1.49–2.10, Phet<0.01; [AA + AG] vs GG: OR =2.03, 95% CI: 1.64–2.53, Phet<0.01; AA vs [AG + GG]: OR =1.72, 95% CI: 1.40–2.12, Phet<0.01; AA vs GG: OR =2.24, 95% CI: 1.69–2.98, Phet<0.01; AG vs GG: OR =1.98, 95% CI: 1.62–2.41, Phet<0.01). Subgroup analysis by cancer type showed that CAV1 G14713A polymorphism was associated with an increased risk of digestive system cancer and other cancer types.
Conclusion: Our findings suggest that CAV1 G14713A polymorphisms may modify the risk of cancer, especially digestive system cancer. However, further well-designed studies are warranted to validate this association.

Keywords: caveolin-1, polymorphism, cancer, susceptibility

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