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Quality of Life of Drug Reaction with Eosinophilia and Systemic Symptom (DRESS) and Stevens-Johnson Syndrome (SJS) and/or Toxic Epidermal Necrolysis (TEN) Patients

Authors Perwitasari DA, Febriana SA, Tristiana RS

Received 4 October 2020

Accepted for publication 19 January 2021

Published 15 February 2021 Volume 2021:15 Pages 329—335

DOI https://doi.org/10.2147/PPA.S285256

Checked for plagiarism Yes

Review by Single anonymous peer review

Peer reviewer comments 3

Editor who approved publication: Dr Johnny Chen


Dyah Aryani Perwitasari,1 Sri Awalia Febriana,2 Ratna Septi Tristiana1

1Faculty of Pharmacy, Universitas Ahmad Dahlan, Yogyakarta, Indonesia; 2Department of Dermatology and Venereology, Universitas Gadjah Mada, Yogyakarta, Indonesia

Correspondence: Dyah Aryani Perwitasari
Faculty of Pharmacy, Universitas Ahmad Dahlan, Kampus 3 UAD, Jl Prof Dr Soepomo, Janturan, Yogyakarta, 55164, Indonesia
Tel/Fax +62274563515
Email dyah.perwitasari@pharm.uad.ac.id

Purpose: Drug Reaction With Eosinophilia and Systemic Symptom (DRESS), Stevens-Johnson Syndrome (SJS), and Toxic Epidermal Necrolysis (TEN) are acute hypersensitivity reactions with the potential to reduce the quality of life of exposed individuals. This study aims to determine the quality of life of patients suffering from DRESS, SJS, SJS/TEN.
Patients and Methods: A cross-sectional approach was used to get the quality of life data from DRESS, SJS, and/or TEN patients at Dr. Sardjito general hospital, Yogyakarta. The utility index and VAS score differences of EQ-5D-5L were analyzed based on the diagnosis.
Results: We recruited 58 patients. Most of the patients were female (63%). The mean value of utility index was 0.61, 0.08 and 0.03 for DRESS, SJS and SJS/TEN patients, respectively (p value < 0.01). Furthermore, the mean of VAS score was 73.36, 57.93 and 50.00 for DRESS, SJS and SJS/TEN patients, respectively (p value < 0.01).
Conclusion: In general, the quality of life of DRESS patients is better than the quality of life of SJS and/or TEN patients.

Keywords: DRESS, QoL, SJS, TEN, skin diseases

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