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QT and P-wave dispersion during the manic phase of bipolar disorder

Authors Gurok MG, Korkmaz H, Yıldız S, Bakış D, Atmaca M

Received 10 March 2019

Accepted for publication 10 June 2019

Published 3 July 2019 Volume 2019:15 Pages 1805—1811

DOI https://doi.org/10.2147/NDT.S208253

Checked for plagiarism Yes

Review by Single-blind

Peer reviewers approved by Dr Colin Mak

Peer reviewer comments 2

Editor who approved publication: Dr Roger Pinder


Mehmet Gurkan Gurok,1 Hasan Korkmaz,2 Sevler Yıldız,1 Dilek Bakış,1 Murad Atmaca1

1Fırat University, School of Medicine, Department of Psychiatry, Elazig, Turkey; 2Fırat University, School of Medicine, Department of Cardiology, Elazig, Turkey

Background and aim: Patients with bipolar disorder (BD) are at increased risk for cardiovascular diseases and complications. This increased risk is considered to be associated with the autonomic nervous system (ANS) abnormalities. However, there is little or no documentation of the relationship between this increased risk and the phases of BD. In this study, we aimed to compare the changes in the QT dispersion (QTd) and P-wave dispersion (Pd), which are predictors of sudden cardiac death and atrial fibrillation, between the patients with manic BD and healthy controls.
Participants and methods: The study included a patient group of 44 patients (26 female and 18 male) that were hospitalized due to a diagnosis of manic BD and met the inclusion criteria, and a control group of 34 age- and gender-matched healthy individuals (21 female and 13 male) with no history of psychiatric and neurological disorders. The QTd and Pd values were determined in each participant by performing the standard 12-lead body surface electrocardiography (ECG).
Results: The principal electrocardiographic indicators including corrected maximum QT interval, corrected QT dispersion, and minimum P-wave duration significantly increased in the patient group compared to the control group (t=2.815, p<0.01; t=4.935, p<0.001; t=3.337, p<0.001, respectively).
Conclusion: The results indicated that patients with manic BD are at increased risk for cardiovascular autonomic dysfunction. Therefore, clinicians should be more careful about ECG changes and related possible cardiac conduction problems such as cardiac arrthythmias in patients with manic BD. Further longitudinal studies are needed to investigate BD and its phases (depression, mania, and hypomania) with regard to ANS and cardiac abnormalities.

Keywords: mania, bipolar disorder, QT dispersion, P-wave dispersion


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