Pulmonary stem cells and the induction of tissue regeneration in the treatment of emphysema
Authors Josephine Lenssen, Jan Stolk
Published 15 July 2007 Volume 2007:2(2) Pages 131—139
Josephine Lenssen, Jan Stolk
Department of Pulmonology, Leiden University Medical Center, Leiden, The Netherlands
Abstract: A common feature of lung disorders with poor treatment options, including emphysema, is a failure to initiate a repair process of the alveolar epithelium. Several putative stem cell niches in the lung thought to be involved in lung homeostasis have been described. Apparently, under pathophysiological conditions these resident progenitor cells are unable to recover damaged alveolar epithelium, in particular in emphysema. The potential therapeutic effect of retinoic acid receptor agonists on various resident lung progenitor cells is reviewed.
Keywords: alveolar growth, repair, emphysema