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Pulmonary Lymphoepithelioma-Like Carcinoma Treated with Immunotherapy or Chemotherapy: A Single Institute Experience

Authors Fu Y, Zheng Y, Wang PP, Chen YY, Ding ZY

Received 12 November 2020

Accepted for publication 18 January 2021

Published 16 February 2021 Volume 2021:14 Pages 1073—1081


Checked for plagiarism Yes

Review by Single anonymous peer review

Peer reviewer comments 2

Editor who approved publication: Prof. Dr. Nicola Silvestris

Yang Fu,* Yue Zheng,* Pei-Pei Wang, Yue-Yun Chen, Zhen-Yu Ding

Department of Biotherapy, Cancer Center, West China Hospital, West China Medical School, Sichuan University, Chengdu, People’s Republic of China

*These authors contributed equally to this work

Correspondence: Zhen-Yu Ding
Department of Biotherapy, Cancer Center, West China Hospital, Sichuan University, Chengdu, 610041, People’s Republic of China
Tel +86 028 8542 2562
Fax +86 028 8516 4059

Background: Lymphoepithelioma-like carcinoma (LELC) is a rare malignant tumor of the lung. It is related to EB virus infection. Epidermal growth factor receptor (EGFR) and anaplastic lymphoma kinase (ALK) are rarely found in this disease, while high level programmed cell death ligand 1 (PD-L1) expression is observed. Here a series of patients with advanced LELC treated with immunotherapy were summarized.
Methods: This retrospective, observational study was conducted in patients who were pathologically confirmed, metastatic or recurrent LELC patients. Patients were prescribed with either chemotherapy or immunotherapy, according to treating physicians’ discretion.
Results: A total of 27 patients were included in our study, 10 with immunotherapy (ICI group) and 17 with chemotherapy (Chemo group). The objective response rates (ORR) of the two groups were 80.0% and 70.5% (p=0.678), and disease control rates (DCR) were 100% and 88.2% (p=0.516). However, the response depth was better in the ICI group. Although the cohort of patients in the ICI group was in a disadvantageous state (both up-front and salvage), the progression-free survival (PFS) was much longer (15.0 and 7.9 m, p=0.005). The 1-year PFS rate in the ICI group was also much higher (40% and 5.9%, p=0.047).
Conclusion: This study implicated the high efficiency of ICI therapy in this disease.

Keywords: lymphoepithelioma-like carcinoma, ICIs, PD-L1, immunotherapy

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