Dr Yang Wang
Consulting Editor: Yang Wang (PhD)
Postdoctoral Research Associate, Department of Biomedical, National Jewish Health, Denver, CO, USA
Major histocompatibility complex (MHC) molecules present peptides to T cell receptor (TCR) to enable T-lymphocytes to recognize epitopes and distinguish self and foreign antigens. The type 1 diabetes is a T cell mediated autoimmune disease associated with certain MHC molecules. My research is based on the recognition mechanism of TCR molecules to peptide bonding MHC-II in type1 diabetes. We use structural biology and immunology methods to investigate the process of peptide presentation, T cell receptor recognition and the regulation of this interaction. The Class II MHC molecules present the antigen fragments to certain T lymphocyte cells, which stimulate the immune reaction. Different alleles of MHC II isotypes have been associated with many chronic inflammatory diseases. With structural biology approaches we will be able to understand the molecular mechanism of different antigen recognition by MHC II and Immune Responses of T cell. Further, we will know how small molecule metal ions such as beryllium and Nickel provoke a hypersensitivity disorder and finally find inhibitors to block or attenuate Allergy reaction. Also with the tri-complex of MHC, peptide and TCR, we will be able to understand how a specific antigen causes the disease and how T cells involve in the progression of the disease.