Dr Rabi Yacoub
Consulting Editor: Rabi Yacoub (M.D.)
Assistant Professor of Medicine, University at Buffalo, Buffalo, NY, USA
My clinical responsibilities including taking care of patients with a wide variety of renal diseases, including but not limited to acute kidney injury (AKI), chronic kidney disease (CKD), glomerulonephritis, polycystic kidney disease and the management of resistant hypertension. I see patients in the floors of Buffalo General Medical Centre (BGMC) and the renal clinics.
My research focuses on finding modifiable factors to reverse or halt the progression of CKD, through modifying the contents of gut bacteria (microbiota) and study its correlation with disease state. Studies have demonstrated that gut microbiota can influence numerous aspects of human biology, and alterations in its function and composition (dysbiosis) have been suggested to play a role in pathogenesis of diverse human illnesses such as chronic inflammation, diabetes mellitus, obesity, cardiovascular diseases and recently, chronic kidney disease.
I am using both human and animal studies to explore the effects of gut microbiota dysbiosis on renal diseases. We have conducted clinical trials evaluating the diversities and population of gut bacteria in patients with different degrees of renal insufficiencies and evaluating the role of diet on gut bacteria and inflammation in patients with end stage renal disease (ESRD) on dialysis.
To confirm the findings and further explore the importance of gut microbiota on renal diseases and conditions, I am conducting animal experiments using different murine models of advanced and acute-reversible renal diseases.
In addition to my research activities, I am supervising and teaching renal fellows, medicine residents and medical students in the renal inpatient rotation, and in the renal outpatient clinic.