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Psychiatric symptoms and leptin in obese patients who were bariatric surgery candidates

Authors Changchien T, Tai C, Huang C, Chien C, Yen Y

Received 7 May 2015

Accepted for publication 9 July 2015

Published 19 August 2015 Volume 2015:11 Pages 2153—2158


Checked for plagiarism Yes

Review by Single anonymous peer review

Peer reviewer comments 3

Editor who approved publication: Professor Wai Kwong Tang

Te-Chang Changchien,1 Chi-Ming Tai,2 Chih-Kun Huang,3 Chia-Chang Chien,1 Yung-Chieh Yen1,4

1Department of Psychiatry, E-Da Hospital, 2Department of Internal Medicine, E-Da Hospital, 3Bariatric and Metabolic International Surgery Center, E-Da Hospital, 4School of Medicine, I-Shou University, Kaohsiung, Taiwan

Objective: There is a significant relationship between obesity and common mental symptoms (depression and anxiety symptoms). But the association between depression (or anxiety symptoms) and serum leptin is still unclear and controversial, despite the growing body of evidence supporting the existence of “leptin resistance” in obese persons. So we investigated whether common mental symptoms, obesity, and the interactive effect of these two factors have a relationship with leptin in obese patients who were candidates for bariatric surgery.
Methods: In all, 139 participants (mean age: 31.4 years, standard deviation: 9.3 years, 73.4% female) were enrolled at an obesity treatment center in southern Taiwan. Serum leptin levels and body mass index (BMI) were measured. The Chinese Health Questionnaire and Taiwanese Depression Questionnaire were administered.
Results: The mean BMI of our participants was 39.4 kg/m2 (±6.8), and the mean leptin level was 24.5 ng/mL (±9.4). In the multivariate regression models, Chinese Health Questionnaire-by-BMI and Taiwanese Depression Questionnaire-by-BMI interaction terms remained significant predictors of leptin level (β=0.16, P<0.0001; β=0.04, P<0.0001, respectively), after adjustment for age, sex, and history of hypertension, diabetes, and hyperlipidemia, despite the inverse correlation between Chinese Health Questionnaire (or Taiwanese Depression Questionnaire) and leptin. In addition, female patients had significantly higher leptin levels than male patients.
Conclusion: The present findings confirmed that the relationship between common mental symptoms and leptin is modulated by obesity in severely obese patients. Future studies should focus on further measures of leptin receptors or signaling on the basis of these interactive effects in psychiatry.

Keywords: leptin, depression, anxiety, common mental disorder, obesity

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