Back to Journals » Neuropsychiatric Disease and Treatment » Volume 7 » Issue 1

Psychiatric disorders in primary focal dystonia and in Parkinson’s disease

Authors Dias F, Kummer, Doyle, Harsanyi, Cardoso, Fontenelle L, Teixeira A

Published 14 March 2011 Volume 2011:7(1) Pages 111—116

DOI https://doi.org/10.2147/NDT.S17507

Review by Single-blind

Peer reviewer comments 3


Fernando MV Dias1, Arthur Kummer1, Flávia CP Doyle2, Estefânia Harsányi1, Francisco Cardoso2, Leonardo F Fontenelle3, Antônio Lúcio Teixeira1
1Neuropsychiatric Branch, 2Movement Disorders Clinic, Neurology Unit, University Hospital, Federal University of Minas Gerais, Belo Horizonte; 3Department of Psychiatry, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil

Background: Primary focal dystonia and Parkinson’s disease are movement disorders that have contrasting motor phenotypes. The aim of this study was to compare the frequency and the severity of psychiatric disorders in primary focal dystonia and Parkinson's disease.
Methods: Two groups of 30 patients matched by gender and age underwent a neurological and psychiatric assessment.
Results: Parkinson’s disease patients were diagnosed with higher rates of major depression (P = 0.02) and generalized anxiety disorder (P = 0.02), and greater severity of depressive symptoms (P = 0.04), while patients with primary focal dystonia exhibited increased severity of obsessive-compulsive symptoms (P = 0.02).
Discussion: The difference in pathophysiology of primary focal dystonia and Parkinson’s disease may explain the different psychiatric profiles of these two diseases. The increased frequency of affective symptoms in Parkinson’s disease may be related to the fact that Parkinson's disease is a neurodegenerative disease marked by the loss of monoaminergic neurons which does not happen in primary focal dystonia.
Conclusion: The psychiatric profile differs in movement disorders with distinct neurobiological bases.

Keywords: focal dystonia, Parkinson’s disease, neuropsychiatry, depression, obsessive-compulsive disorder

Creative Commons License This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution - Non Commercial (unported, v3.0) License. By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms.

Download Article [PDF]  View Full Text [HTML][Machine readable]