Back to Browse Journals » Psoriasis: Targets and Therapy » Volume 2

Psoriasis: epidemiology, natural history, and differential diagnosis

Authors Basko-Plluska JL, Petronic-Rosic V

Received 30 May 2012

Accepted for publication 16 July 2012

Published 11 September 2012 Volume 2012:2 Pages 67—76


Checked for plagiarism Yes

Review by Single-blind

Peer reviewer comments 3

Juliana L Basko-Plluska, Vesna Petronic-Rosic

Department of Medicine, Section of Dermatology, University of Chicago, Chicago, IL, USA

Abstract: Psoriasis is a chronic, immune-mediated, inflammatory disease which affects primarily the skin and joints. It occurs worldwide, but its prevalence varies considerably between different regions of the world. Genetic susceptibility as well as environmental factors play an important role in determining the development and prognosis of psoriasis. Genome-wide association studies have identified many genetic loci as potential psoriasis susceptibility regions, including PSORS1 through PSORS7. Histocompatibility antigen (HLA) studies have also identified several HLA antigens, with HLA-Cw6 being the most frequently associated antigen. Epidemiological studies identified several modifiable risk factors that may predispose individuals to developing psoriasis or exacerbate pre-existing disease. These include smoking, obesity, alcohol consumption, diet, infections, medications and stressful life events. The exact mechanism by which they trigger psoriasis remains to be elucidated; however, existing data suggest that they are linked through Th1-mediated immunological pathways. The natural history of psoriasis varies depending on the clinical subtype as well as special circumstances, including pregnancy and HIV infection. In general, psoriasis is a chronic disease with intermittent remissions and exacerbations. The differential diagnosis is vast and includes many other immune-mediated, inflammatory disorders.

Keywords: psoriasis, epidemiology, natural history, differential diagnosis

Creative Commons License This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at and incorporate the Creative Commons Attribution - Non Commercial (unported, v3.0) License. By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms.

Download Article [PDF] 


Readers of this article also read:

Epidemiology and treatment of psoriasis: a Brazilian perspective

Duarte GV, Porto-Silva L, Oliveira MdeFP

Psoriasis: Targets and Therapy 2015, 5:55-64

Published Date: 17 April 2015

Emerging treatment options for psoriasis

Taheri A, Sandoval LF, Moradi Tuchayi S, Alinia H, Mansoori P, Feldman SR

Psoriasis: Targets and Therapy 2014, 4:27-35

Published Date: 18 August 2014

Self-management in patients with psoriasis

Pathak SN, Scott PL, West C, Feldman SR

Psoriasis: Targets and Therapy 2014, 4:19-26

Published Date: 10 July 2014

Long-term safety of biologics in the treatment of psoriasis

Panchal MR, Coope H, McKenna DJ, Alexandroff AB

Psoriasis: Targets and Therapy 2014, 4:1-9

Published Date: 12 December 2013

Retinal vascular tortuosity in obstructive sleep apnea

Mohsenin A, Mohsenin V, Adelman RA

Clinical Ophthalmology 2013, 7:787-792

Published Date: 26 April 2013

Role of T-cell-mediated inflammation in psoriasis: pathogenesis and targeted therapy

Flatz L, Conrad C

Psoriasis: Targets and Therapy 2013, 3:1-10

Published Date: 27 February 2013

Biomarkers in the pathogenesis, diagnosis, and treatment of psoriasis

Molteni S, Reali E

Psoriasis: Targets and Therapy 2012, 2:55-66

Published Date: 4 September 2012


Wu Q, Chu M

International Journal of Nanomedicine 2012, 7:4531-4532

Published Date: 15 August 2012

The management of psoriasis through diet

Duarte G, Barbosa LO, Rosa ME

Psoriasis: Targets and Therapy 2012, 2:45-53

Published Date: 7 August 2012

Quality of life issues and measurement in patients with psoriasis

Tan X, Feldman SR, Balkrishnan R

Psoriasis: Targets and Therapy 2012, 2:13-23

Published Date: 21 February 2012