Back to Journals » Clinical Ophthalmology » Volume 3

Proton beam radiotherapy in the management of uveal melanoma: Clinical experience in Scotland

Authors Aziz S, Taylor A, McConnachie A, Kacperek A, Kemp E

Published 28 August 2008 Volume 2009:3 Pages 49—55

DOI https://doi.org/10.2147/OPTH.S3555

Review by Single-blind

Peer reviewer comments 2


Samir Aziz1, Alex Taylor1, Andrzej McConnachie3, Alex Kacperek2, Ewan Kemp1

1Tennent Institute of Ophthalmology, Gartnavel General Hospital, Glasgow, Scotland, UK; 2Clatterbridge Centre for Oncology, Wirral, England, UK; 3Robertson Centre for Biostatistics, University of Glasgow, Glasgow, Scotland, UK

Aim: To evaluate proton-beam radiotherapy (PBRT) in the management of uveal melanoma in Scotland.

Methods: A retrospective review was undertaken on all patients receiving PBRT for uveal melanoma (1994–2005). Data obtained included: gender, past ocular/medical history, age, presenting complaint(s), diagnosis, laterality, tumor location/ultrasound characteristics, visual acuity (VA) and intraocular pressure. At post-treatment reviews (3, 6, 12, and 24 months), the following data was obtained: VA, intraocular pressure, tumor appearance and ultrasound characteristics. Mean follow up was 38.8 months.

Results: Seventy-six patients were included. Mean age was 64 years; male to female ratio was 1.1:1. Ninety-seven percent demonstrated initial treatment response; 87% had successful control of tumor growth. Mean pre-treatment tumor height was 6.2 mm v.s. 4.8 mm post-irradiation (p < 0.001). Pre-irradiation VA was <3/60 in 18.5% compared with 74% post-irradiation (p < 0.0001). There was a statistically significant association between adverse events (enucleation, metastasis) and greater maximal basal tumor diameter. Eighteen eyes were enucleated. The median survival time was estimated to be 54 months.

Conclusion: In our experience, PBRT is a precise, reliable and effective treatment in the management of large, and previously treated uveal melanomas. It prevents enucleation in the majority at short term follow-up.

Keywords: proton-beam radiotherapy, uveal melanoma, visual acuity, enucleation, tumor

Creative Commons License This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution - Non Commercial (unported, v3.0) License. By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms.

Download Article [PDF]