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Prostate cancer imaging: positron-emission tomography perspectives

Authors Ibrahim N, Cho SY

Received 22 October 2014

Accepted for publication 20 December 2014

Published 15 April 2015 Volume 2015:8 Pages 51—62

DOI https://doi.org/10.2147/RMI.S45315

Checked for plagiarism Yes

Review by Single-blind

Peer reviewer comments 3

Editor who approved publication: Professor Tarik Massoud


Nevein Ibrahim, Steve Y Cho

Department of Radiology, Nuclear Medicine Section, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA


Abstract: There is a pressing demand for more accurate characterization of prostate cancer to provide risk-adapted patient-specific therapy, especially with the recent development of a growing repertoire of treatment options. This trend toward more personalized care has resulted in a need for improved prostate-specific imaging in order to provide image-guided therapy and facilitate treatment monitoring. In addition to these clinical needs, there is a growing vision and challenge for new molecular imaging techniques not only to detect tumors but also provide important information regarding tumor biology and prognosis. This review presents a perspective on prostate cancer imaging, summarizing current conventional imaging approaches with a focus on emerging and future positron emission tomography-based radiotracers at different clinical and preclinical stages of development.

Keywords: prostate cancer, positron-emission tomography, molecular imaging, single photon-emission computed tomography, prostate-specific membrane antigen

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