Proportion of Acute Transfusion Reaction and Associated Factors Among Adult Transfused Patients at Felege Hiwot Compressive Referral Hospital, Bahir Dar, Northwest Ethiopia: A Cross-Sectional Study
Authors Gelaw Y, Woldu B, Melku M
Received 20 February 2020
Accepted for publication 17 June 2020
Published 30 June 2020 Volume 2020:11 Pages 227—236
Checked for plagiarism Yes
Review by Single-blind
Peer reviewer comments 2
Editor who approved publication: Dr Martin H Bluth
Yemataw Gelaw,1,2 Berhanu Woldu,2 Mulugeta Melku2
1Amhara Regional Health Bureau, Bahir Dar, Ethiopia; 2Department of Hematology & Immunohematology, School of Biomedical and Laboratory Sciences, College of Medicine and Health Sciences, University of Gondar, Gondar, Ethiopia
Correspondence: Yemataw Gelaw
Amhara Regional Health Bureau, Bahir Dar, Ethiopia
Introduction: Acute transfusion reactions are adverse events occurring within 24 hrs of transfusion and cause simple-to-severe complications. They may vary with the blood component transfused and recipient factors. In Ethiopia, there is a limited evidence about the incidence and associated factors of transfusion reactions.
Objective: To determine the proportion of acute transfusion reactions and associated factors among adult transfused patients.
Methods: A total of 384 study participants were included in the study. Structured questionnaires were used for socio-demographic and past medical history data collection. Vital signs were measured as a baseline for every study participants and monitored and followed for 24 hrs. Laboratory tests like complete blood count, direct anti-human globulin test and urine hemoglobin were done as a baseline for suspected patients. Cross-match, blood grouping, and blood culture for patients and donors sample were also done for suspected patients. Descriptive statistics, bivariable and multivariable binary logistic regression were analyzed using SPSS version 20. P-value of < 0.05 in the multivariable model was considered as statistically significant.
Results: Acute transfusion reactions were observed in 5.2% of patients. Of total cases of acute transfusion reaction, the majority developed allergic reactions (65%) and febrile non-hemolytic transfusion reaction (30%). It was significantly associated with transfusion history (AOR=3.4; 95% CI: 1.2– 9.7), abortion history (AOR=5.0; 95% CI: 1.5– 16.4), longer blood storage time (AOR=5.1; 95% CI: 1.7– 15.2) and receiving three or more unit of blood (AOR= 4.1; 95% CI: 1.5– 11.2).
Conclusion: Acute transfusion reactions were observed in 5.2% of patients (allergic reactions (65%), febrile non-hemolytic transfusion reaction (30%) and alloimmunization (5%)). Patients with a history of transfusion, abortion, transfused with blood stored ≥ 14 days and multi-transfused patients should be closely monitored.
Keywords: acute transfusion reaction, adverse event, blood transfusion, transfusion reaction, Ethiopia
This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution - Non Commercial (unported, v3.0) License. By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms.Download Article [PDF] View Full Text [HTML][Machine readable]