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Progress toward overcoming hypoxia-induced resistance to solid tumor therapy

Authors Karakashev S, Reginato M

Received 9 May 2015

Accepted for publication 14 June 2015

Published 12 August 2015 Volume 2015:7 Pages 253—264

DOI https://doi.org/10.2147/CMAR.S58285

Checked for plagiarism Yes

Review by Single-blind

Peer reviewer comments 3

Editor who approved publication: Professor Kenan Onel


Video abstract presented by Sergey V Karakashev.

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Sergey V Karakashev, Mauricio J Reginato

Department of Biochemistry and Molecular Biology, Drexel University College of Medicine, Philadelphia, PA, USA

Abstract: Hypoxic tumors are associated with poor clinical outcome for multiple types of human cancer. This may be due, in part, to hypoxic cancer cells being resistant to anticancer therapy, including radiation therapy, chemotherapy, and targeted therapy. Hypoxia inducible factor 1, a major regulator of cellular response to hypoxia, regulates the expression of genes that are involved in multiple aspects of cancer biology, including cell survival, proliferation, metabolism, invasion, and angiogenesis. Here, we review multiple pathways regulated by hypoxia/hypoxia inducible factor 1 in cancer cells and discuss the latest advancements in overcoming hypoxia-mediated tumor resistance.

Keywords: HIF-1, cancer, chemoresistance, signaling, apoptosis

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