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Progress of Nanotechnology in Diabetic Retinopathy Treatment

Authors Liu Y, Wu N

Received 27 December 2020

Accepted for publication 5 February 2021

Published 24 February 2021 Volume 2021:16 Pages 1391—1403

DOI https://doi.org/10.2147/IJN.S294807

Checked for plagiarism Yes

Review by Single anonymous peer review

Peer reviewer comments 2

Editor who approved publication: Dr Ebrahim Mostafavi


Yuxin Liu,1 Na Wu2,3

1Student Affairs Department, Shengjing Hospital of China Medical University, Shenyang, 110004, People’s Republic of China; 2Department of Endocrinology, Shengjing Hospital of China Medical University, Shenyang, 110004, People’s Republic of China; 3Clinical Skills Practice Teaching Center, Shengjing Hospital of China Medical University, Shenyang, 110004, People’s Republic of China

Correspondence: Na Wu
Shengjing Hospital of China Medical University, Shenyang, 110004, People’s Republic of China
Email 3441535223@qq.com

Abstract: Diabetic retinopathy (DR) is a chronic diabetes complication that progressively manifests itself as blurred vision, eye floaters, distorted vision, and even partial or total loss of vision as a result of retinal detachment in severe cases. Clinically, patients who have undergone variations in the microcirculation of the ocular fundus are treated with laser photocoagulation to improve the circulation of retina; but for patients with macular edema, anti-vascular endothelial growth factor (anti-VEGF) drugs are generally injected to eliminate macular edema and improve vision. The worst cases are patients with fundus hemorrhage or proliferative vitreoretinopathy, for whom vitrectomy has been performed. At present, these clinical treatment methods have widely been used, providing satisfactory results. However, considering the low bioavailability and potential side effects of drugs and the inevitable risks in major surgery, DR prevention, and treatment as well as nerve tissue regeneration in the later stage have always been the focus of research. In recent years, nanotechnology has been increasingly applied in the medical field, leading to new ideas for DR treatment. This study aims to systematically review the research progress of nanotechnology in DR treatment.

Keywords: diabetes mellitus, diabetic retinopathy, nanotechnology, drug delivery

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