Back to Journals » Cancer Management and Research » Volume 11

Prognostic value of miR17-92 family in patients with digestive system cancers: a systematic review and meta-analysis

Authors Zhang X, Zhang S, He Q, Gao X, Yang L, Xu P, Zhao R, Wang Q, Zhang L, Zhao P

Received 28 September 2018

Accepted for publication 22 December 2018

Published 22 January 2019 Volume 2019:11 Pages 1043—1058

DOI https://doi.org/10.2147/CMAR.S189113

Checked for plagiarism Yes

Review by Single-blind

Peer reviewers approved by Dr Andrew Yee

Peer reviewer comments 2

Editor who approved publication: Professor Nakshatri


Xiaoyun Zhang,1 Shijie Zhang,1 Qin He,1 Xiaojuan Gao,1 Lijun Yang,1 Peipei Xu,2 Rui Zhao,2 Qian Wang,3 Lina Zhang,4 Panpan Zhao5

1Department of Clinical Laboratory, First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan 450052, China; 2Department of Clinical Laboratory, Third Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan 450052, China; 3Department of Medical Laboratory, Fuwai Central China Cardiovascular Hospital, Zhengzhou, Henan 450052, China; 4Blood Transfusion Room, Fuwai Central China Cardiovascular Hospital, Zhengzhou, Henan 450052, China; 5Department of Clinical Laboratory, People’s Liberation Army 159 Hospital, Zhumadian, Henan 463000, China

Abstract: The miR17-92 family is found to be aberrantly expressed and associated with clinicopathological characteristics in patients with various cancers, including digestive system cancers. However, its prognostic value is not yet established. Therefore, we performed a systematic review and meta-analysis to investigate the association between miR17-92-family expression and clinical outcomes in digestive system cancers. We searched the PubMed, Web of Science, Embase, and CNKI (Chinese) databases to retrieve eligible studies up to June 30, 2018. Prognostic data and clinicopathological features of overall survival (OS), disease-free survival (DFS), and progression-free survival (PFS) were extracted to evaluate correlations of the miR17-92 family with digestive system cancers. We used HRs to assess association between miR17-92-family expression and cancers prognosis. A total of 30 qualifying studies involving 4,056 subjects were included in this meta-analysis. Our results indicated that expression levels of miR17-92 can predict poor OS (HR 1.21, 95% CI 1.03–1.39; P=0). However, there was no relationship between the miR17-92 family and DFS (HR 0.86, 95% CI 0.6–1.11; P=0.170) or PFS (HR 1.37, 95% CI 0.83–1.91; P=0). Moreover, miR17-92 was related to TNM stage (III/IV vs I/II, HR 1.37, 95% CI 1.17–1.570; P=0.012), but there was no relationship between miR17-92 and metastasis (HR 1.64, 95% CI 1.34–1.95; P=0.491) or tumor size (≥5 cm vs <5 cm, HR 1.29, 95% CI 1.09–1.49; P=0.586). Subgroup analysis showed that miR17-92 expression was associated with poor OS among the Chinese subgroup (HR 1.28, 95% CI 1.08–1.48; P=0) and tissue samples (HR 1.12, 95% CI 0.93–1.31; P=0), while there was no association with other characteristics. Our results indicated that miR17-92 expression is significantly associated with poor survival in patients with digestive system cancers, suggesting that miR17-92 may be a romising prognostic marker to monitor prognosis and progression of cancers.
 
Keywords: miR17-92 family, prognosis, digestive system cancer, meta-analysis

Creative Commons License This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution - Non Commercial (unported, v3.0) License. By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms.

Download Article [PDF]  View Full Text [HTML][Machine readable]