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Prognostic value of miR-17-5 p in gastrointestinal cancers: a systematic review and meta-analysis

Authors Wang Z, Zhang J, Zhang Z, Jiang Y, Li M, Li Q, Bai L, Yao D, Wang M, Wang X

Received 21 November 2017

Accepted for publication 20 May 2018

Published 19 September 2018 Volume 2018:11 Pages 5991—5999

DOI https://doi.org/10.2147/OTT.S157670

Checked for plagiarism Yes

Review by Single-blind

Peer reviewers approved by Dr Cristina Weinberg

Peer reviewer comments 4

Editor who approved publication: Dr Jianmin Xu


Zeyu Wang,1 Jing Zhang,2 Zhiguang Zhang,2 Yong Jiang,2 Man Li,2 Qian Li,2 Lu Bai,2 Dongying Yao,1 Miao Wang,1 Xiaoping Wang1

1Department of Gastroenterology, Shanghai University of Medicine & Health Sciences Affiliated Zhoupu Hospital, Shanghai, 201318, China; 2Department of Gastroenterology, The Second Hospital of Tianjin Medical University, Tianjin, 300211, China

Background: There are accumulating studies investigating the aberrant expression of microRNAs in tumor patients. As an important member of miR-17/92 cluster, miR-17-5 p has been identified as a potential prognostic factor for survival in tumor patients. We conducted this meta-analysis aimed to assess the effect of miR-17-5 p as a prognostic biomarker for gastrointestinal tumor patients.
Materials and methods: Eligible studies were enrolled by searching the online databases of PubMed, Embase, Web of Science, China National Knowledge Infrastructure, and WanFang Data until September 2017. We calculated pooled hazard ratios (HRs) and 95% CI of miR-17-5 p for overall survival and disease-free survival.
Results: In the categorical variable analysis, we identified 11 studies with 1,279 patients. The pooled analyses suggested that overexpression of miR-17-5 p may predict poor overall survival (HR = 1.86, 95% CI: 1.55–2.25, P<0.001) and disease-free survival (HR = 1.43, 95% CI: 1.01–2.03, P=0.046) in patients with gastrointestinal tumors. Subgroup analysis showed the pooled HR of overall survival was more significant in tissue specimen, Asian patients, and digestive tract tumors. But there was no correlation between the outcomes and European patients.
Conclusions: This meta-analysis suggested that miR-17-5 p has predictive effects on overall survival and disease-free survival of patients with gastrointestinal tumors.

Keywords: miR-17-5 p, mircoRNA-17-5p, prognosis, survival, meta-analysis

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