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Prognostic significance of serum lactate dehydrogenase in patients with breast cancer: a meta-analysis

Authors Liu D, Wang D, Wu C, Zhang L, Mei Q, Hu G, Long G, Sun W

Received 22 December 2018

Accepted for publication 21 March 2019

Published 26 April 2019 Volume 2019:11 Pages 3611—3619

DOI https://doi.org/10.2147/CMAR.S199260

Checked for plagiarism Yes

Review by Single-blind

Peer reviewers approved by Dr Andrew Yee

Peer reviewer comments 2

Editor who approved publication: Dr Antonella D'Anneo


Dongbo Liu,1 Dingkun Wang,2 Cheng Wu,1 Linli Zhang,1 Qi Mei,1 Guangyuan Hu,1 Guoxian Long,1 Wei Sun1

1Department of Oncology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430030, People’s Republic of China; 2Department of Integrated Traditional Chinese and Western Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430030, People’s Republic of China

Background: Multiple studies have assessed the prognostic significance of serum lactate dehydrogenase (LDH) in patients with breast cancer, but their results remain controversial. This study aimed to evaluate the prognostic value of LDH in breast cancer by meta-analysis.
Methods: Electronic searches for relevant articles were conducted in PubMed, Embase and Web of Science databases. The HR and their 95% CI were used to assess the prognostic value of serum LDH. Stata Statistical Software 12.0 was applied for statistical analysis.
Results: A total of 11 studies involving 6,102 patients were subjected to final analysis. Our results showed that higher serum LDH had significant effect on poor overall survival (HR, 1.88; 95% CI, 1.68–2.11) and progression-free survival (HR, 1.98; 95% CI, 1.46–2.68). Moreover, the results of subgroup analyses were consistent with that of overall outcomes. No significant heterogeneity and publication bias were found in this study.
Conclusion: Serum LDH could act as a prognostic factor for patients with breast cancer. Future data are needed to validate and update our results.

Keywords: breast cancer, lactate dehydrogenase, prognosis, biomarker, meta-analysis

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