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Prognostic role of serum C-reactive protein in esophageal cancer: a systematic review and meta-analysis

Authors Huang Y, Feng J, Liu J, Chen Q

Received 11 July 2014

Accepted for publication 11 September 2014

Published 14 January 2015 Volume 2015:11 Pages 89—94


Checked for plagiarism Yes

Review by Single-blind

Peer reviewer comments 3

Editor who approved publication: Professor Garry Walsh

Ying Huang,1 Ji-Feng Feng,2 Jin-Shi Liu,2 Qi-Xun Chen2

1Department of Operating Theatre, 2Department of Thoracic Surgery, Zhejiang Cancer Hospital, Hangzhou, People’s Republic of China

Background: Recent studies have shown that C-reactive protein (CRP) is a useful predictive factor in several cancers; however, its role in esophageal cancer (EC) is controversial.
Methods: A systematic literature search was performed using Medline, PubMed, and Web of Science to analyze the prognostic value of serum CRP in patients with EC. A meta-analysis was performed to assess the association between serum CRP and overall survival (OS) in patients with EC.
Results: A total of eight studies involving 1,471 patients were included in our study. Our pooled results demonstrated that a high level of serum CRP was associated with poor OS (hazard ratio [HR]: 1.40, 95% confidence interval [CI]: 1.25–1.57, I2=81.3%, P<0.0001). Subgroup analyses were performed in further investigations. When the patients were segregated according to treatment, pathological type, and cut-off level, high levels of serum CRP were found to be significantly correlated with OS.
Conclusion: Our meta-analysis revealed that high levels of serum CRP were significantly associated with poor OS in patients with EC.

Keywords: CRP, esophageal cancer, meta-analysis

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