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Prognostic role of microRNA-150 in various carcinomas: a meta-analysis

Authors Wang W, Wang X, Zhang Y, Wang D, Gao H, Wang L, Gao S

Received 10 October 2015

Accepted for publication 7 January 2016

Published 11 March 2016 Volume 2016:9 Pages 1371—1379

DOI https://doi.org/10.2147/OTT.S97969

Checked for plagiarism Yes

Review by Single-blind

Peer reviewers approved by Dr Nitin Kumar Agarwal

Peer reviewer comments 3

Editor who approved publication: Professor Daniele Santini


Wei Wang, Xinshuai Wang, Yali Zhang, Dan Wang, Hui Gao, Lijuan Wang, Shegan Gao

Henan Key Laboratory of Cancer Epigenetics, Cancer Institute, The First Affiliated Hospital, and College of Clinical Medicine of Henan University of Science and Technology, Luoyang, Henan, People’s Republic of China

Objective:
MicroRNA-150 (miR-150) was revealed to be an attractive prognostic biomarker in recent studies. However, the prognostic significance of miR-150 expression in cancer remains inconclusive. The aim of this study was to summarize the global predicting role of miR-150 in survival in patients with various carcinomas.
Methods: Eligible studies were identified through multiple search strategies. Data were extracted from the studies by investigating the relationship between miR-150 expression and survival in patients with cancer. A meta-analysis of the hazard ratio (HR) was then performed to evaluate the prognostic role of miR-150 in different tumors. Pooled HRs of miR-150 for overall survival and progression-free survival were calculated to measure the effect of miR-150 expression on prognosis.
Results: This meta-analysis included nine published studies concerning various carcinomas. Our results indicate that an elevated miR-150 expression is associated with an enhanced overall survival in the digestive tract cancer subgroup (HR =0.57, 95% confidence interval [CI]: 0.37–0.90) and a poor progression-free survival in various cancers (HR =3.08, 95% CI: 2.00–4.75).
Conclusion: miR-150 may have the potential to become a new useful prognostic factor to monitor cancer prognosis and progression. However, given the current insufficient relevant data, further clinical studies are needed.

Keywords: microRNA-150, carcinomas, prognosis, meta-analysis

A Letter to the Editor has been received and published for this article. 


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