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Prognostic role of long non-coding RNA HNF1A-AS1 in Chinese cancer patients: a meta-analysis

Authors Zhuang C, Zheng L, Wang P

Received 25 January 2018

Accepted for publication 27 June 2018

Published 31 August 2018 Volume 2018:11 Pages 5325—5332

DOI https://doi.org/10.2147/OTT.S163575

Checked for plagiarism Yes

Review by Single-blind

Peer reviewers approved by Dr Colin Mak

Peer reviewer comments 2

Editor who approved publication: Dr Jianmin Xu


Chunbo Zhuang,1 Lei Zheng,1 Pei Wang2

1
Department of Clinical Laboratory Medicine, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, People’s Republic of China; 2Department of Gastroenterology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, People’s Republic of China

Background: Long non-coding RNAs (LncRNAs) play important roles in tumorigenesis and progression. Recent studies have demonstrated that LncRNA HNF1A antisense RNA 1 (HNF1A-AS1) is aberrantly expressed in several types of cancers and is associated with poor outcomes. This meta-analysis was conducted to investigate the relationship between HNF1A-AS1 expression and clinical outcomes in cancer patients.
Methods: We searched PubMed, Embase, Web of Science, China National Knowledge Infrastructure (CNKI), and Wan Fang databases (updated until December 31, 2017) for literature. A total of eight studies with 789 cancer patients were finally included in the present meta-analysis.
Results: The results showed that high expression of HNF1A-AS1 significantly predicted poor overall survival (HR=3.10, 95% CI: 1.58–6.11, P=0.001), which was further validated using The Cancer Genome Atlas (TCGA) dataset. Moreover, high HNF1A-AS1 expression was also associated with advanced TNM stage (OR=3.32, 95% CI: 2.28–4.83, P<0.001), lymph node metastasis (OR=3.08, 95% CI: 1.95–4.85, P<0.001), and distant metastasis (OR=5.53, 95% CI: 1.94–15.77, P=0.001).
Conclusion: Our results suggested that elevated HNF1A-AS1 was associated with poor clinical outcomes and might serve as a potential prognostic biomarker of cancer.

Keywords:
cancer, overall survival, TCGA, long non-coding RNA, HNF1A-AS1, meta-analysis

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