Prognostic Factors for Penile Cancer and Survival in Response to Multimodality Therapy
Authors Sirithanaphol W, Sookprasert A, Rompsaithong U, Kiatsopit P, Wirasorn K, Chindaprasirt J
Received 11 November 2019
Accepted for publication 28 January 2020
Published 12 February 2020 Volume 2020:12 Pages 29—34
Checked for plagiarism Yes
Review by Single-blind
Peer reviewer comments 2
Editor who approved publication: Dr Jan Colli
Wichien Sirithanaphol,1 Aumkhae Sookprasert,2 Ukrit Rompsaithong,1 Pakorn Kiatsopit,1 Kosin Wirasorn,2 Jarin Chindaprasirt2
1Division of Urologic Surgery, Department of Surgery, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand; 2Division of Medical Oncology, Department of Internal Medicine, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand
Correspondence: Jarin Chindaprasirt
Division of Medical Oncology, Department of Internal Medicine, Faculty of Medicine, Khon Kaen University, Khon Kaen 40002, Thailand
Tel +66 43 363 664
Fax +66 43 202 491
Purpose: To report treatment outcomes of penile cancer in a single institution in Thailand and to identify prognostic factors for survival, highlighting the crucial role of multi-modality treatment (MMT).
Patients and Methods: Squamous cell carcinoma of penis patients who were treated at Srinagarind hospital between 2007– 2015 were retrospectively analyzed. Clinical and pathological data were retrospectively reviewed. Overall survival (OS) was calculated using the Kaplan-Meier method and data were compared using the Log rank test. Cox regression analysis of factors affecting survival was conducted.
Results: A total of 70 patients were identified with a median follow-up of 69.4 months. Twenty-eight patients (40%) presented with early-stage (stage I or II), whereas 42 patients (60%) were stage III or IV disease. The median OS was 29.3 months (Interquartile range 10.5 months - not reached) for the entire cohort. Nodal involvement was the only factor identified from the multivariate model with the adjusted HR or 5.74 (95% CI 2.52– 13.04). For patients with stage IIIB/IV, multi-modality treatment (MMT) resulted in longer survival when compared with surgery alone (HR 0.37; 95% CI 0.16– 0.90).
Conclusion: Patients with penile cancer in Thailand presented with younger age and more locally advanced stage. Nodal involvement is the single poor prognostic factor for OS and MMT was associated with longer survival in stage IIIB/IV disease.
Keywords: penile neoplasms, penile diseases, radiation, squamous cell
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