Back to Journals » Clinical and Experimental Gastroenterology » Volume 7

Profile of ustekinumab and its potential in patients with moderate-to-severe Crohn's disease

Authors Tuskey A, Behm B

Received 18 November 2013

Accepted for publication 3 February 2014

Published 23 May 2014 Volume 2014:7 Pages 173—179

DOI https://doi.org/10.2147/CEG.S39518

Checked for plagiarism Yes

Review by Single-blind

Peer reviewer comments 5


Anne Tuskey, Brian W Behm

Division of Gastroenterology and Hepatology, University of Virginia School of Medicine, Charlottesville, VA, USA

Abstract: The advent of anti-tumor necrosis factor (TNF)-α therapy has been a major advance in the medical management of Crohn's disease (CD). However, a significant proportion of patients with CD do not respond adequately to treatment with these agents. Primary and secondary nonresponse to anti-TNFα therapy represents a common clinical challenge, and highlights the need for the development of additional medication options for CD. The proinflammatory cytokines interleukin (IL)-12 and IL-23 are thought to play a key role in the pathogenesis of CD, and serve as a potential target for additional biologic therapies. Monoclonal antibodies targeting IL-12/23 have shown efficacy in animal models of colitis, and are currently being studied in Phase III clinical trials of CD. This review focuses on ustekinumab, a fully human immunoglobulin G1 monoclonal antibody, which blocks activity of IL-12 and IL-23 through binding the p40 subunit, and describes the current efficacy and safety data for ustekinumab in patients with CD.

Keywords: Crohn's disease, ustekinumab, clinical trials, inflammatory bowel disease


Creative Commons License This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution - Non Commercial (unported, v3.0) License. By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms.

Download Article [PDF]  View Full Text [HTML][Machine readable]