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Profile of infliximab in the treatment of pediatric Crohn’s disease

Authors Kierkus J, Szymanska E, Oracz G, Wiernicka A, Dadalski M

Received 31 December 2014

Accepted for publication 7 March 2015

Published 11 June 2015 Volume 2015:6 Pages 79—85

DOI https://doi.org/10.2147/PHMT.S64943

Checked for plagiarism Yes

Review by Single-blind

Peer reviewer comments 4

Editor who approved publication: Professor Laurens Holmes, Jr


Jaroslaw Kierkus,1 Edyta Szymanska,2 Grzegorz Oracz,1 Anna Wiernicka,1 Maciej Dadalski1

1Department of Gastroenterology, Hepatology, Feeding Disorders and Pediatrics, 2Department of Pediatrics, Nutrition and Metabolic Disorders, The Children’s Memorial Health Institute, Warsaw, Poland

Abstract: In recent years, a novel biologic therapy with monoclonal antibodies against tumor necrosis factor-alpha has revolutionized the treatment of Crohn’s disease. Infliximab, the first biologic agent, has been demonstrated to considerably improve both clinical and endoscopic outcomes. In view of the growing popularity of infliximab in the management of Crohn’s disease, we review the profile of the agent in the treatment of this disease in a pediatric setting.

Keywords: infliximab, Crohn’s disease, children, biologic therapy, anti-TNF-agents

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