Back to Journals » OncoTargets and Therapy » Volume 6

Profile of erlotinib and its potential in the treatment of advanced ovarian carcinoma

Authors Hirte HW

Received 27 October 2012

Accepted for publication 28 December 2012

Published 18 April 2013 Volume 2013:6 Pages 427—435


Checked for plagiarism Yes

Review by Single anonymous peer review

Peer reviewer comments 4

Hal W Hirte

Department of Oncology, McMaster University, Hamilton, ON, Canada

Abstract: The epidermal growth-factor receptor (EGFR) is overexpressed in the majority of epithelial ovarian cancers and promotes cell proliferation, migration and invasion, and angiogenesis, as well as resistance to apoptosis. This makes EGFR an attractive therapeutic target in this disease. A number of strategies to block EGFR activity have been developed, including small-molecular-weight tyrosine kinase inhibitors such as erlotinib. Erlotinib has been evaluated as a single agent in recurrent ovarian cancer, as well as in combination with chemotherapeutic agents in the first-line and recurrent settings, and in combination with the antiangiogenic agent bevacizumab in the recurrent setting, as well as in the maintenance setting after completion of first-line chemotherapy. Unfortunately, erlotinib has shown only minimal efficacy as a single agent, and it has not enhanced the effects of chemotherapy or bevacizumab when combined with these agents. Ongoing and future studies of erlotinib and other agents blocking EGFR will need to define mechanisms resulting in resistance to such interventions, and to validate biomarkers of response to identify patients most likely to benefit from such approaches.

Keywords: ovarian cancer, epidermal growth factor, epidermal growth-factor receptor, erlotinib, tyrosine kinase inhibitor

Creative Commons License © 2013 The Author(s). This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at and incorporate the Creative Commons Attribution - Non Commercial (unported, v3.0) License. By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms.