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Profile of darunavir in the treatment of HIV-infected pediatric and adolescent patients

Authors Dobroszycki, Abadi J, Wiznia A, Rosenberg

Published 14 September 2011 Volume 2011:2 Pages 85—93

DOI https://doi.org/10.2147/AHMT.S11177

Review by Single-blind

Peer reviewer comments 3


Joanna Dobroszycki, Jacobo Abadi, Andrew A Wiznia, Michael G Rosenberg
Department of Pediatrics, Division of Infectious Diseases, Jacobi Medical Center, Bronx, NY, USA

Abstract: The introduction of protease inhibitors (PI) containing antiretroviral regimens in the treatment of HIV infection in infants, children, and adolescents has dramatically decreased morbidity and mortality. Darunavir, the latest PI to be FDA approved for pediatric patients older than 6 years and currently the preferred PI for use in adult patients, was added as an alternative PI for use in children based on a combination of data from both adult and pediatric trials. This review of darunavir in the treatment of HIV-infected children and adolescents looks at the major published clinical trials findings, pharmacokinetic and resistance studies, and preliminary data on use in younger children.

Keywords: darunavir, HIV, protease inhibitor

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