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Profile of darunavir in the management of treatment-experienced HIV patients

Authors Wolfe C, Hicks C

Published 29 September 2009 Volume 2009:1 Pages 13—21

DOI https://doi.org/10.2147/HIV.S4842

Review by Single-blind

Peer reviewer comments 2


Cameron Wolfe, Charles Hicks

Duke University Medical Center, Division of Infectious Diseases, Durham, NC, USA

Abstract: Darunavir (formerly TMC114) is a second-generation, sulfonamide-based, peptidomimetic protease inhibitor (PI) with a modified 3-dimensional structure enabling more efficient binding to HIV protease. It has become an important drug, in combination with low-dose ritonavir boosting, in the treatment of both antiretroviral-naïve and multiclass-experienced patients. Growing data now exist suggesting it possesses a high barrier to resistance and requires multiple PI mutations in order to suffer reduced virological potency.

Keywords: darunavir, HIV, ritonavir

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