Back to Archived Journals » Botanics: Targets and Therapy » Volume 5

Profile of crofelemer for the symptomatic treatment of diarrhea in HIV-infected persons

Authors Leonard C, Chordia P, MacArthur R

Received 28 April 2014

Accepted for publication 11 July 2014

Published 7 January 2015 Volume 2015:5 Pages 21—25


Checked for plagiarism Yes

Review by Single anonymous peer review

Peer reviewer comments 3

Christina Leonard,1 Poorvi Chordia,1 Rodger D MacArthur1,2

1Department of Infectious Diseases, Wayne State University, Detroit, MI, USA; 2Newland Immunology Center of Excellence, Southfield, MI, USA

Abstract: Diarrhea due to noninfectious causes is a major problem in human immunodeficiency virus (HIV)-infected persons, and is frequently related to antiretroviral therapy and HIV-associated enteropathy. Crofelemer is a first-in-class antidiarrheal agent that is United States Food and Drug Administration approved for noninfectious diarrhea in persons with HIV on antiretroviral therapy. Crofelemer is derived from the blood-red sap of Croton lechleri, a South American plant whose latex is associated with various healing attributes. In fact, it has a unique effect on chloride channels in the gastrointestinal lumen, and leads to decreased efflux of sodium molecules and water, thereby decreasing the frequency of stools. Crofelemer – a plant-based compound, discovered and investigated as the result of the increased prevalence of ethnobotany – is a novel and effective agent with a good safety profile. It could potentially improve the quality of life for HIV-infected patients and hopefully, in turn, will improve antiretroviral therapy compliance.

Keywords: chloride channels, secretory diarrhea, botanical, sangre de grado, intra-luminal

Creative Commons License This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at and incorporate the Creative Commons Attribution - Non Commercial (unported, v3.0) License. By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms.

Download Article [PDF]  View Full Text [HTML][Machine readable]