Back to Journals » Lung Cancer: Targets and Therapy » Volume 5

Profile of bavituximab and its potential in the treatment of non-small-cell lung cancer

Authors Stasi I, Cappuzzo F

Received 30 March 2014

Accepted for publication 6 May 2014

Published 28 August 2014 Volume 2014:5 Pages 43—50

DOI https://doi.org/10.2147/LCTT.S37981

Checked for plagiarism Yes

Review by Single-blind

Peer reviewer comments 5


Video abstract presented by Irene Stasi.

Views: 282

Irene Stasi, Federico Cappuzzo

Medical Oncology Department, Istituto Toscano Tumori, Ospedale Civile, Livorno, Italy

Abstract: Bavituximab is a an unconjugated, chimeric immunoglobulin G1 (IgG1) monoclonal antibody directed against the phosphatidylserine (PS) expressed on tumor endothelium, with a specific mechanism of action. PS is an anionic membrane phospholipid, physiologically restricted to the internal membrane leaflet; various pathophysiologic processes cause the exposure of PS on the external membrane leaflet. Bavituximab, once bound, starts up host effector activities, such as antibody dependent cellular cytotoxicity, causing vessel destruction and enhancing antitumor immunity. Phase I clinical trials of bavituximab administered as monotherapy or in combination with other chemotherapeutic agents in adults with pretreated solid tumors have been accomplished, indicating that bavituximab can be safely dispensed weekly, with a recommended dose of 1 and 3 mg/kg. A Phase II randomized, placebo-controlled trial of bavituximab plus docetaxel, in the second-line therapy setting of locally advanced or metastatic non-small-cell lung cancer, has been conducted and recently presented, suggesting a clinical benefit of the combination, with an overall response rate of 17% and median overall survival of more than 11 months. A Phase III trial is currently ongoing. Bavituximab has been studied in combination with platinum-based doublets with promising results. In the present paper we summarize the preclinical development and clinical experience with bavituximab in non-small-cell lung cancer.

Keywords: bavituximab, NSCLC, targeted therapy, vascular disrupting agent, vascular targeting agent

Creative Commons License This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution - Non Commercial (unported, v3.0) License. By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms.

Download Article [PDF]  View Full Text [HTML][Machine readable]