Back to Journals » International Journal of Chronic Obstructive Pulmonary Disease » Volume 10 » Issue 1

Profile of a fixed-dose combination of tiotropium/olodaterol and its potential in the treatment of COPD

Authors Muruganandan S, Jayaram L

Received 15 December 2014

Accepted for publication 20 April 2015

Published 18 June 2015 Volume 2015:10(1) Pages 1179—1189


Checked for plagiarism Yes

Review by Single-blind

Peer reviewer comments 2

Editor who approved publication: Dr Richard Russell

Sanjeevan Muruganandan,1 Lata Jayaram2,3

1Department of Respiratory and Sleep Medicine, Austin Health, 2Department of Respiratory and Sleep Medicine, Western Health, 3University of Melbourne, Melbourne, Victoria, Australia

Abstract: Chronic obstructive pulmonary disease (COPD) is a progressive, debilitating disorder that results in frequent exacerbations and impacts quality of life. It represents a growing burden of health care cost, both from societal and economic perspectives. Short- and long-acting bronchodilators remain the mainstay of therapy in COPD patients. New fixed-dose combination inhalers with novel pharmacological combinations of long-acting β2-agonists and muscarinic antagonists and delivered once-daily through a variety of devices are currently being developed and licensed for the treatment of COPD. There is mounting research suggesting that combining a fixed dose of a β2-agonist and a muscarinic antagonist achieves better bronchodilation and clinical outcomes compared with either agent alone. These once-daily dosing inhalers are anticipated to impact favorably on patient preference and compliance. This review examines the fixed-dose combination of tiotropium bromide and olodaterol delivered by a Respimat® Soft Mist™ inhaler at doses of 2.5/5 µg and 5/5 µg in moderate-to-very-severe COPD, and its potential role in COPD compared with other long-acting β2-agonist with long-acting muscarinic antagonist combinations and delivery devices.

Keywords: fixed-dose combination inhalers, olodaterol, tiotropium bromide, COPD treatment, long-acting β2-agonists, long-acting muscarinic antagonist

Creative Commons License This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at and incorporate the Creative Commons Attribution - Non Commercial (unported, v3.0) License. By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms.

Download Article [PDF]  View Full Text [HTML][Machine readable]


Readers of this article also read:

Forecasting COPD hospitalization in the clinic: optimizing the chronic respiratory questionnaire

Abascal-Bolado B, Novotny PJ, Sloan JA, Karpman C, Dulohery MM, Benzo RP

International Journal of Chronic Obstructive Pulmonary Disease 2015, 10:2295-2301

Published Date: 22 October 2015

Positioning new pharmacotherapies for COPD

Barjaktarevic IZ, Arredondo AF, Cooper CB

International Journal of Chronic Obstructive Pulmonary Disease 2015, 10:1427-1442

Published Date: 24 July 2015

Evaluating inhaler use technique in COPD patients

Pothirat C, Chaiwong W, Phetsuk N, Pisalthanapuna S, Chetsadaphan N, Choomuang W

International Journal of Chronic Obstructive Pulmonary Disease 2015, 10:1291-1298

Published Date: 8 July 2015

Test-retest reliability of lower limb isokinetic endurance in COPD: a comparison of angular velocities

Ribeiro F, Lépine PA, Garceau-Bolduc C, Coats V, Allard E, Maltais F, Saey D

International Journal of Chronic Obstructive Pulmonary Disease 2015, 10:1163-1172

Published Date: 18 June 2015

Screening of COPD patients for abdominal aortic aneurysm

Flessenkaemper IH, Loddenkemper R, Roll S, Enke-Melzer K, Wurps H, Bauer TT

International Journal of Chronic Obstructive Pulmonary Disease 2015, 10:1085-1091

Published Date: 10 June 2015

LANTERN: a randomized study of QVA149 versus salmeterol/fluticasone combination in patients with COPD

Zhong N, Wang C, Zhou X, Zhang N, Humphries M, Wang L, Thach C, Patalano F, Banerji D

International Journal of Chronic Obstructive Pulmonary Disease 2015, 10:1015-1026

Published Date: 5 June 2015

Novel aspects of pathogenesis and regeneration mechanisms in COPD

Bagdonas E, Raudoniute J, Bruzauskaite I, Aldonyte R

International Journal of Chronic Obstructive Pulmonary Disease 2015, 10:995-1013

Published Date: 2 June 2015