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Primary spinal epidural diffuse large B-cell lymphoma with paraplegia as the first manifestation: a case report

Authors Shu Y, Wang A, Yi L, Xu X, Yang W

Received 30 May 2019

Accepted for publication 2 August 2019

Published 14 August 2019 Volume 2019:12 Pages 6497—6501

DOI https://doi.org/10.2147/OTT.S217703

Checked for plagiarism Yes

Review by Single-blind

Peer reviewers approved by Ms Rachel Predeepa

Peer reviewer comments 2

Editor who approved publication: Dr Nicola Silvestris


Yefei Shu,1 Anlong Wang,2 Li Yi,3 Xiaofeng Xu,1 Wei Yang1

1Department of Oncology and Hematology, Zhejiang Provincial Integrated Chinese and Western Medicine Hospital (Hangzhou Red Cross Hospital), Hangzhou, People’s Republic of China; 2Department of Radiology, Zhejiang Provincial Integrated Chinese and Western Medicine Hospital (Hangzhou Red Cross Hospital), Hangzhou, People’s Republic of China; 3Departments of Pathology, Zhejiang Provincial Integrated Chinese and Western Medicine Hospital (Hangzhou Red Cross Hospital), Hangzhou, People’s Republic of China

Abstract: Primary spinal epidural diffuse large B-cell lymphoma (DLBCL) is rare and often easily misdiagnose. Here, we presented a case of primary spinal epidural DLBCL with paraplegia as the first manifestation. He was misdiagnosed as thoracic disc herniation and thoracic tuberculosis successively. DLBCL was confirmed after surgery ultimately. After 6 cycles of chemotherapy with R-CHOPE, the patient went back to normal life without relapse during 2-year follow-up. Primary spinal epidural lymphoma should be suspected in patients with spinal cord compression with imaging showing isointense, homogeneous extradural contiguous level compressive soft‑tissue lesion without bony involvement and previous history of cancer.

Keywords: epidural, diffuse large B-cell lymphoma


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