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Primary ovarian insufficiency: an update

Authors Cox L, Liu J

Received 5 November 2013

Accepted for publication 25 December 2013

Published 20 February 2014 Volume 2014:6 Pages 235—243

DOI https://doi.org/10.2147/IJWH.S37636

Checked for plagiarism Yes

Review by Single-blind

Peer reviewer comments 3


Leticia Cox, James H Liu

UH Case Medical Center, MacDonald Women's Hospital, Department of Obstetrics and Gynecology, Case Western Reserve University School of Medicine, Department of Reproductive Biology, Cleveland, OH, USA

Abstract: Primary ovarian insufficiency is a condition that represents impaired ovarian function on a continuum with intermittent ovulation. This condition commonly leads to premature menopause, defined as cessation of ovulation prior to the age of 40 years. Because there are potential immediate and long-term consequences of hypoestrogenism, a timely diagnosis is invaluable. This comprehensive review will discuss identifiable causes for primary ovarian insufficiency, including genetic disorders and metabolic abnormalities, as well as review current strategies for diagnosis, evaluation, and management of women with this condition.

Keywords: premature ovarian failure, premature menopause, ovarian dysfunction

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