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Primary Osteosarcoma of the Breast with Extensive Chondroid Matrix in a Teenager Female Patient: The Paradoxical Diagnosis in Breast Mastopathy

Authors Yahaya JJ, Odida M

Received 8 October 2019

Accepted for publication 28 December 2019

Published 10 January 2020 Volume 2020:13 Pages 11—17

DOI https://doi.org/10.2147/IMCRJ.S233674

Checked for plagiarism Yes

Review by Single-blind

Peer reviewer comments 2

Editor who approved publication: Professor Ronald Prineas


James Joseph Yahaya, 1, 2 Michael Odida 1

1Department of Pathology, Makerere College of Health Sciences (MakCHS), Kampala, Uganda; 2Department of Biomedical Sciences, College of Health Sciences (CHS), the University of Dodoma, Dodoma, Tanzania

Correspondence: James Joseph Yahaya
Department of Pathology, Makerere College of Health Sciences (MakCHS), P.O. Box 7072, Kampala, Uganda
Tel +256 784 847 139
Email jayame76@gmail.com

Purpose: Non-epithelial tumors of the breast are extremely rare and have an incidence of less than 1%. The most common non-epithelial breast tumor is the phyllodes tumor (PT), which accounts for 61%. Primary osteosarcomas of the breast contribute up to only 12.5% of all breast sarcomas. In young females, osteosarcomas are extremely rare, especially in those without a previous history of primary bone osteosarcoma. A case of a 16-year old female with primary osteosarcoma of the breast (POB) with extensive chondroid matrix involving the left breast is herein presented.
Case Report: This report describes a 16-year old female with neither a previous history of bone osteosarcoma nor family history of breast cancer who was diagnosed with a primary chondroblastic osteosarcoma of the left breast. The mass was shining, warm, firm, and slightly fixed. The excisional biopsy showed a large tumor measuring 11x9x7 cm which was encapsulated, grayish-white, and nodular.
Conclusion: Primary osteosarcomas of the breast carry a poor prognosis by being triple negative and because of being the rarest tumors, they pose a challenge in managing the patients due to lack of established treatment modalities.

Keywords: osteosarcoma, breast, triple negative


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