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Prevention of stent thrombosis: challenges and solutions

Authors Reejhsinghani R, Lotfi AS

Received 8 August 2014

Accepted for publication 25 October 2014

Published 27 January 2015 Volume 2015:11 Pages 93—106

DOI https://doi.org/10.2147/VHRM.S43357

Checked for plagiarism Yes

Review by Single-blind

Peer reviewer comments 2

Editor who approved publication: Dr Daniel Duprez

Risheen Reejhsinghani, Amir S Lotfi

Division of Cardiology, Baystate Medical Center, Springfield, MA, USA

Abstract: Stent thrombosis is an uncommon but serious complication which carries with it significant mortality and morbidity. This review analyzes the entity of stent thrombosis from a historical and clinical perspective, and chronicles the evolution of this condition through the various generations of stent development, from bare metal to first-generation, second-generation, and third-generation drug-eluting stents. It also delineates the specific risk factors associated with stent thrombosis and comprehensively examines the literature related to each of these risks. Finally, it highlights the preventative strategies that can be garnered from the existing data, and concludes that a multifactorial approach is necessary to combat the occurrence of stent thrombosis, with higher risk groups, such as patients with ST segment elevation myocardial infarction, meriting further research.

Keywords: stent thrombosis, preventative strategies, post-procedural myocardial infarction

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