Prevention of maternal cytomegalovirus infection: current status and future prospects

Jessica L Nyholm¹, Mark R Schleiss²

¹Department of Obstetrics, Gynecology, and Women’s Health, and ²Department of Pediatrics, University of Minnesota School of Medicine, Minneapolis, MN, USA

Abstract: Human cytomegalovirus (CMV) infection is the most common cause of perinatal viral infection in the developed world, resulting in approximately 40,000 congenitally infected infants in the United States each year. Congenital CMV infection can produce varying degrees of neurodevelopmental disabilities. The significant impact of congenital CMV has led the Institute of Medicine to rank development of a CMV vaccine as a top priority. Vaccine development has been ongoing; however no licensed CMV vaccine is currently available. Treatment of pregnant women with CMV hyperimmune globulin has shown promising results, but has not been studied in randomized controlled trials. Education on methods to prevent CMV transmission, particularly among young women of child-bearing age, should continue until a CMV vaccine becomes available. The epidemiology, clinical manifestations, prevention strategies, and treatment of CMV infections are reviewed.

Keywords: cytomegalovirus, CMV vaccines, congenital CMV, CMV infection, immunoglobulin