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Prevention of diabetes in hypertensive patients: Results and implications from the VALUE trial

Authors Zhou M, Schulman IH

Published 16 April 2009 Volume 2009:5 Pages 361—368

DOI https://doi.org/10.2147/VHRM.S4331

Review by Single-blind

Peer reviewer comments 3


Ming-Sheng Zhou, Ivonne Hernandez Schulman

Nephrology-Hypertension Section, Veterans Affairs Medical Center and Division of Nephrology and Hypertension and Vascular Biology institute, University of Miami Miller School of Medicine, Miami, FL, USA

Abstract: A growing number of experimental and clinical studies have provided evidence indicating that pharmacological blockade of the renin–angiotensin system (RAS) by either angiotensin-converting enzyme inhibitors or angiotensin type 1 receptor blockers reduces the incidence of new onset type 2 diabetes in subjects with hypertension and/or cardiovascular disease, independently of antihypertensive and cardiovascular protective effects. The beneficial effects of RAS inhibition on the development of diabetes have been largely attributed to improvements in peripheral insulin sensitivity and glucose metabolism. This review focuses on recent experimental and clinical evidence supporting the role of RAS inhibition in the reduction of new onset type 2 diabetes and the mechanisms that may be involved.

Keywords: renin–angiotensin system, antihypertensive, diabetes

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